Effect of bisphosphonate as an adjunct treatment for chronic periodontitis on gingival crevicuar fluid levels of nuclear factor-B-K ligand (RANKL) and osteoprotegerin in postmenopausal osteoporosis
| Autor: | Özgür Korhan Tunçel, Birşen Bilgici, Feyzi Gokosmanoglu, Feyza Otan Özden, Elif Eser Sakallıoğlu, Esra Demir, Aysegul Atmaca |
|---|---|
| Přispěvatelé: | DEMİR, ESRA, OMÜ |
| Rok vydání: | 2017 |
| Předmět: |
non-surgical periodontal treatment
Male musculoskeletal diseases medicine.medical_specialty bisphosphonate medicine.medical_treatment Osteoporosis 030209 endocrinology & metabolism Enzyme-Linked Immunosorbent Assay Group A Gastroenterology Group B 03 medical and health sciences 0302 clinical medicine Osteoprotegerin Internal medicine medicine Humans Receptor General Dentistry periodontitis Osteoporosis Postmenopausal biology Diphosphonates business.industry RANK Ligand RANKL 030206 dentistry Gingival Crevicular Fluid Bisphosphonate Middle Aged medicine.disease Chronic periodontitis osteoporosis Case-Control Studies Chronic Periodontitis biology.protein OPG Female business |
| Popis: | TUNCEL, OZGUR KORHAN/0000-0002-2989-5894 WOS: 000399263300018 PubMed: 28367895 Osteoporosis and periodontal disease are linked by an altered receptor activator of nuclear factor B-K ligand and osteoprotegerin ratio (RANKL/OPG), and medical treatment with bisphosphonate (BP) may help control these molecules. The effect of BP on clinical findings and gingival crevicular fluid (GCF) values of RANKL and OPG using enzyme-linked immunosorbent assays was evaluated in postmenopausal women; 13 patients with both chronic periodontitis and osteoporosis (group A), 12 systemically healthy patients with chronic periodontitis (group B), 12 periodontally healthy patients with osteoporosis (group C), and 10 systemically and periodontally healthy individuals (group D). Recordings were repeated at the end of months 1, 6, and 12 in groups A, B, and C. At the baseline, groups A and B exhibited the lowest OPG values (P < 0.05). After periodontal treatment, OPG values were markedly increased at the end of 6th month in group A and 12th month in group B (P < 0.008). There was no significant difference in GCF RANKL values among groups (P > 0.05) or during the observation period (P > 0.008). The use of BP may be effective in preventing periodontal breakdown by controlling the levels of these markers in osteoporosis as an adjunct to periodontal treatment. Ondokuz Mayis University Research FoundationOndokuz Mayis University [PYO.DIS.1901.13.010] The study was financially supported by a grant from the Ondokuz Mayis University Research Foundation (PYO.DIS.1901.13.010). |
| Databáze: | OpenAIRE |
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