The effect of long-term high frequency repetitive transcranial magnetic stimulation on working memory in schizophrenia and healthy controls—A randomized placebo-controlled, double-blind fMRI study

Autor: Thomas Wobrock, Lydia Gibson, Katrin Obst, Peter Dechent, Andrew M. McIntosh, Alkomiet Hasan, Heather C. Whalley, Peter Falkai, Birgit Guse, Boris Suchan, Oliver Gruber
Rok vydání: 2013
Předmět:
Adult
Male
medicine.medical_specialty
medicine.medical_treatment
Neuropsychological Tests
Audiology
behavioral disciplines and activities
Young Adult
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
Double-Blind Method
Image Processing
Computer-Assisted
medicine
Humans
Middle frontal gyrus
Psychiatry
Cognitive deficit
Psychiatric Status Rating Scales
Analysis of Variance
Brain Mapping
Memory Disorders
medicine.diagnostic_test
Working memory
Brain
Cognition
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Transcranial Magnetic Stimulation
030227 psychiatry
Oxygen
Dorsolateral prefrontal cortex
Transcranial magnetic stimulation
Memory
Short-Term
Treatment Outcome
medicine.anatomical_structure
Schizophrenia
Female
medicine.symptom
Functional magnetic resonance imaging
Psychology
030217 neurology & neurosurgery
Zdroj: Behavioural Brain Research. 237:300-307
ISSN: 0166-4328
Popis: In schizophrenia patients negative symptoms and cognitive impairment often persist despite treatment with second generation antipsychotics leading to reduced quality of life and psychosocial functioning. One core cognitive deficit is impaired working memory (WM) suggesting malfunctioning of the dorsolateral prefrontal cortex. High frequency repetitive transcranial magnetic stimulation (rTMS) has been used to transiently facilitate or consolidate neuronal processes. Pilot studies using rTMS have demonstrated improvement of psychopathology in other psychiatric disorders, but a systematic investigation of working memory effects outlasting the stimulation procedure has not been performed so far. The aim of our study was to explore the effect of a 3-week high frequency active or sham 10 Hz rTMS on cognition, specifically on working memory, in schizophrenia patients (n=25) in addition to antipsychotic therapy and in healthy controls (n=22). We used functional magnetic resonance imaging (fMRI) to compare activation patterns during verbal WM (letter 2-back task) before and after 3-weeks treatment with rTMS. Additionally, other cognitive tasks were conducted. 10 Hz rTMS was applied over the left posterior middle frontal gyrus (EEG electrode location F3) with an intensity of 110% of the individual resting motor threshold (RMT) over a total of 15 sessions. Participants recruited the common fronto- parietal and subcortical WM network. Multiple regression analyses revealed no significant activation differences over time in any contrast or sample. According to the ANOVAs for repeated measures performance remained without alterations in all groups. This is the first fMRI study that has systematically investigated this topic within a randomized, placebo-controlled, double-blind design, contrasting the effects in schizophrenia patients and healthy controls.
Databáze: OpenAIRE
Externí odkaz: