Vasculogenic Mimicry Formation Is Associated with Erythropoietin Expression but Not with Erythropoietin Receptor Expression in Cervical Squamous Cell Carcinoma
Autor: | Li Xiang, Yue-Jie Li, Xin Qing, Qing-Xu Tao, Tie-Jun Zhou, Li Gong |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
CD31
Adult Article Subject Carcinogenesis lcsh:Medicine General Biochemistry Genetics and Molecular Biology hemic and lymphatic diseases medicine Receptors Erythropoietin Humans Vasculogenic mimicry Erythropoietin Neoplasm Staging Cervical cancer General Immunology and Microbiology Neovascularization Pathologic business.industry lcsh:R Cancer General Medicine Middle Aged medicine.disease Erythropoietin receptor Gene Expression Regulation Neoplastic Squamous intraepithelial lesion Lymphatic Metastasis Cancer research Immunohistochemistry Female Squamous Intraepithelial Lesions of the Cervix business medicine.drug Research Article |
Zdroj: | BioMed Research International BioMed Research International, Vol 2019 (2019) |
ISSN: | 2314-6141 2314-6133 |
Popis: | Background. Vasculogenic mimicry (VM), as an endothelium-independent cancer microcirculation, has been observed in many malignancies including cervical cancer. Erythropoietin (EPO) and erythropoietin receptor (EPO-R) could produce an angiogenic effect to promote cervical squamous cell carcinoma (CSCC) progression. However, the association between VM formation and EPO/EPO-R expression in CSCC is poorly explored. Methods. Seventy-six paraffin-embedded CSCC samples, 25 high-grade squamous intraepithelial lesion (HSIL) samples, 20 low-grade squamous intraepithelial lesion (LSIL) samples, and 20 normal cervix samples were collected. Immunohistochemistry SP method was performed to detect EPO/EPO-R expression and CD31/periodic acid-Schiff (PAS) double staining was performed to detect VM formation. The associations of EPO/EPO-R and VM with clinicopathological parameters of CSCC were analyzed. The associations between VM formation and EPO/EPO-R expression were also analyzed. Results. The positive expression rates of EPO and EPO-R were gradually increasing along the progression of normal cervix-LSIL-HSIL-CSCC sequence (PP>0.05). VM was significantly associated with FIGO stage, lymphovascular space involvement, and lymph node metastasis (Pr=0.284, PP>0.05). Conclusion. These data suggest that increased EPO/EPO-R expression may play an important role in cervical carcinogenesis. EPO overexpression may promote VM formation in CSCC. |
Databáze: | OpenAIRE |
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