Vitamin D status, serum lipid concentrations, and vitamin D receptor (VDR) gene polymorphisms in familial mediterranean fever
| Autor: | Yaşar Karaaslan, Ahmet Yeşilyurt, Turan Turhan, Halef Okan Doğan, Nihal Boğdaycioğlu, Nilnur Eyerci, Ismail Sari, Ahmet Omma |
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| Přispěvatelé: | 0-Belirlenecek, Turhan, T., Department of Biochemistry, Ankara Numune Training and Research Hospital, Ankara, Turkey -- Doğan, H.O., Department of Biochemistry, Faculty of Medicine, University of Cumhuriyet, Sivas, Turkey -- Boğdaycioğlu, N., Department of Biochemistry, Samsun Training and Research Hospital, Samsun, Turkey -- Eyerci, N., Department of Medical Biology, University of Kafkas, Kars, Turkey -- Omma, A., Department of Rheumatology, Ankara Numune Training and Research Hospital, Ankara, Turkey -- Sari, İ., Department of Biochemistry, Faculty of Medicine, University of Niğde Ömer Halis Demir, Niğde, Turkey -- Yeşilyurt, A., Department of Genetics, Dıskapı Yıldırım Beyatız Education and Training Hospital, Ankara, Turkey -- Karaaslan, Y., Department of Rheumatology, Ankara Numune Training and Research Hospital, Ankara, Turkey |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Familial Mediterranean fever Blood lipids Calcitriol receptor chemistry.chemical_compound 25(OH)D3 0302 clinical medicine Polymorphism (computer science) Vitamin D lcsh:R5-920 Sex Characteristics biology General Medicine Vitamins Middle Aged Lipids FokI ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS Female InformationSystems_MISCELLANEOUS lcsh:Medicine (General) Research Article Adult medicine.medical_specialty TaqI Adolescent Genotype VDR polymorphisms Nutritional Status 030209 endocrinology & metabolism 03 medical and health sciences Young Adult FMF Internal medicine medicine Vitamin D and neurology Humans Serum lipids Triglycerides Calcifediol 030203 arthritis & rheumatology Polymorphism Genetic business.industry Cholesterol Cholesterol HDL ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS medicine.disease Endocrinology ComputingMethodologies_PATTERNRECOGNITION chemistry biology.protein Receptors Calcitriol business |
| Zdroj: | Bosnian Journal of Basic Medical Sciences, Vol 18, Iss 1 (2018) |
| Popis: | PubMed ID: 28926322 Vitamin D (VitD) is critical for the regulation of inflammatory processes, and VitD deficiency has been linked to several chronic inflammatory disorders. We aimed to investigate the concentrations of serum 25(OH)D3, lipid parameters, and three known VDR polymorphisms (BsmI, FokI, and TaqI) in patients with Familial Mediterranean fever (FMF), an autosomal recessive autoinflammatory disease. The study included 123 FMF patients and 105 controls. Seventy patients had no attack (group 1), 30 had 1-2 attacks (group 2), and 23 had 3 or more attacks (group 3) within last three months. Serum 25(OH)D3 concentrations were determined using liquid chromatography–tandem mass spectrometry. BsmI, FokI, and TaqI polymorphisms were analyzed by a competitive allele specific polymerase chain reaction assay (KASPar). Serum lipid parameters were measured with enzymatic colorimetric methods. 25(OH)D3 concentrations were lower in FMF patients compared to controls (p < 0.001). No difference was observed in 25(OH)D3 concentration between groups 1, 2, and 3. The distributions of FokI and TaqI genotypes were not significantly different between FMF patients and controls. There was a significant difference in the distribution of AA BsmI genotype between male FMF patients and male controls. Increased concentrations of triglycerides (p = 0.012) and decreased concentrations of high-density lipoprotein cholesterol [HDL-C] (p = 0.006) were found in FMF patients compared to controls. Although lower 25(OH)D3 concentrations were observed in FMF patients versus controls, no association was determined between FMF attack frequency and 25(OH)D3 concentrations. We showed that the AA genotype of BsmI polymorphism is associated with FMF in males but not in females. The effects of decreased HDL-C and increased triglyceride concentrations on cardiovascular events in FMF patients should be further investigated. © 2018 ABMSFBIH. |
| Databáze: | OpenAIRE |
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