SA113. Dopamine D1 Receptor Activation Improves Reward-Associative Learning in a Mouse Probabilistic Learning Task

Autor:	David E. Nichols, Morgane Milienne-Petiot, Jared W. Young, Elizabeth W. Twamley, Mark A. Geyer, Mary Graves
Rok vydání:	2017
Předmět:	business.industry Schizophrenia (object-oriented programming) Probabilistic logic Associative learning Task (project management) Abstracts Psychiatry and Mental health Dopamine receptor D1 Text mining Dopamine medicine Amphetamine Psychology business medicine.drug Cognitive psychology
Zdroj:	Schizophrenia Bulletin. 43:S153-S154
ISSN:	1745-1701 0586-7614
Popis:	Background: Patients with schizophrenia (SZ) exhibit numerous cognitive deficits that negatively impact their global functioning. Reward-associative learning deficits of SZ patients may be particularly important given that most efficacious behavioral therapies utilize reward learning-based programs to improve global functioning. Because the dopamine D1 receptor (D1R) has been implicated in the direct dopamine pathway underlying reward-associative learning, we assessed whether indirect or direct activation of these receptors would improve such learning.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed5493847e20066edbebefc59e95f03 https://doi.org/10.1093/schbul/sbx023.111 Zobrazit plný text záznamu