Characterization of morphine-induced hyperalgesia in male and female rats
| Autor: | Joseph R. Holtman, Elzbieta P. Wala |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Analgesic Rats Sprague-Dawley chemistry.chemical_compound Internal medicine medicine Noxious stimulus Animals Ketamine Neurotransmitter Pain Measurement Sex Characteristics Dose-Response Relationship Drug Morphine business.industry Drug Tolerance Receptor antagonist Rats Anesthesiology and Pain Medicine Endocrinology Neurology chemistry Opioid Hyperalgesia Female Neurology (clinical) medicine.symptom business medicine.drug |
| Zdroj: | Pain. 114:62-70 |
| ISSN: | 0304-3959 |
| DOI: | 10.1016/j.pain.2004.11.014 |
| Popis: | The pain enhancing (hyperalgesic) effect of morphine was characterized in relation to pain stimulus (thermal, mechanical), dose, mode of administration (acute, chronic), sex and mechanism. We found that a low (subanalgesic) dose of morphine enhanced the sensitivity to thermal and mechanical noxious stimuli in a dose- and sex-related manner. Morphine hyperalgesia was inversely related to dose (0.002–0.2 mg/kg) and was more pronounced in female than male rats. The N -methyl- d -aspartate receptor antagonist, ketamine, antagonized morphine hyperalgesia. Tolerance developed to hyperalgesia following repeated (chronic) dosing with low dose morphine. Several additional findings were noted in rats tolerant to morphine-induced hyperalgesia. The efficacy of an analgesic dose of morphine was increased (female rats). Sex-related differences in morphine's analgesic action (male>female) were attenuated. Development of tolerance to the analgesic effect of morphine was delayed. The present findings may have an implication for the use of mu opioids in the clinical setting. |
| Databáze: | OpenAIRE |
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