Adolescent development of neuron structure in dentate gyrus granule cells of male syrian hamsters
Autor: | Liana R. Nichols, Kalynn M. Schulz, Julia L. Zehr, Cheryl L. Sisk |
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Rok vydání: | 2008 |
Předmět: |
Male
Silver Staining Dendritic spine Dendritic Spines Article Sholl analysis Cellular and Molecular Neuroscience Developmental Neuroscience Cricetinae medicine Animals Cell Size Neurons Analysis of Variance Mesocricetus biology Dentate gyrus Granule (cell biology) Age Factors biology.organism_classification Granule cell Electrophysiology medicine.anatomical_structure Animals Newborn nervous system Dentate Gyrus Soma Neuroscience |
Zdroj: | Developmental Neurobiology. 68:1517-1526 |
ISSN: | 1932-846X 1932-8451 |
Popis: | Hippocampal function, including spatial cognition and stress responses, matures during adolescence. In addition, hippocampal neuron structure is modified by gonadal steroid hormones, which increase dramatically at this time. This study investigated pubertal changes in dendritic complexity of dentate gyrus neurons. Dendrites, spines, and cell bodies of Golgi-impregnated neurons from the granule cell layer were traced in pre-, mid-, and late-pubertal male Syrian hamsters (21, 35, and 49 days of age). Sholl analysis determined the number of intersections and total dendritic length contained in concentric spheres set at 25-microm increments from the soma. Spine densities were quantified separately in proximal and distal segments of a subset of neurons used for the Sholl analysis. We found that the structure of neurons in the lower, but not upper, blade of the dentate gyrus changed during adolescence. The lower, infrapyramidal blade showed pruning of dendrites close to the cell body and increases in distal dendritic spine densities across adolescence. These data demonstrate that dentate gyrus neurons undergo substantial structural remodeling during adolescence and that patterns of maturation are region specific. Furthermore, these changes in dendrite structure, which alter the electrophysiological properties of granule cells, are likely related to the adolescent development of hippocampal-dependent cognitive functions such as learning and memory, as well as hippocampus-mediated stress responsivity. |
Databáze: | OpenAIRE |
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