Generation of 500-Member Library of 10-Alkyl-2-R1,3-R2-4,10-Dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-ones
| Autor: | Nikolay Yu. Gorobets, Vladimir I. Musatov, Sergey M. Desenko, Svetlana M. Sirko |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Benzimidazole
Magnetic Resonance Spectroscopy Alkylation Stereochemistry Pharmaceutical Science Antineoplastic Agents Pyrimidinones Article benzimidazole Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound lcsh:Organic chemistry Drug Discovery Dihydrobenzo[4 5]imidazo[1 2-a]pyrimidin-4-one library Physical and Theoretical Chemistry dihydrobenzo[4 5]imidazo[1 2-α]pyrimidin-4-one library Alkyl chemistry.chemical_classification regioselective alkylation Organic Chemistry Regioselectivity anti-cancer agents chemistry Chemistry (miscellaneous) Molecular Medicine |
| Zdroj: | Molecules, Vol 14, Iss 12, Pp 5223-5234 (2009) Molecules Volume 14 Issue 12 Pages 5223-5234 |
| ISSN: | 1420-3049 |
| Popis: | Representative benzimidazopyrimidinones were previously reported to be intercalating antitumor agents. In this work, we used 2-substituted 4,10-dihydrobenzo Dihydrobenzo[4,5]imidazo[1,2-a]pyriminin-4-ones for their diversification by regioselective alkylation. Under the conditions established, the alkylation gave 10-alkyl derivatives which permitted the parallel generation of a 500-member library of the title compounds. |
| Databáze: | OpenAIRE |
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