KLIFS
| Autor: | Iwan J. P. de Esch, Chris de Graaf, Albert J. Kooistra, Bart A. Westerman, Georgi K. Kanev |
|---|---|
| Přispěvatelé: | Neurosurgery, Chemistry and Pharmaceutical Sciences, AIMMS |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
AcademicSubjects/SCI00010 Research Biology Ligands World Wide Web 03 medical and health sciences Annotation 0302 clinical medicine Drug development SDG 3 - Good Health and Well-being 030220 oncology & carcinogenesis Research community Genetics Drug approval Database Issue Databases Protein Protein Kinase Inhibitors Protein Kinases 030304 developmental biology |
| Zdroj: | Kanev, G K, de Graaf, C, Westerman, B A, de Esch, I J P & Kooistra, A J 2021, ' KLIFS : an overhaul after the first 5 years of supporting kinase research ', Nucleic acids research, vol. 49, no. D1, pp. D562-D569 . https://doi.org/10.1093/nar/gkaa895 Nucleic Acids Research Kanev, G K, de Graaf, C, Westerman, B A, de Esch, I J P & Kooistra, A J 2021, ' KLIFS : an overhaul after the first 5 years of supporting kinase research ', Nucleic Acids Research, vol. 49, no. D1, pp. D562-D569 . https://doi.org/10.1093/nar/gkaa895 Nucleic Acids Research, 49(D1), D562-D569. Oxford University Press Nucleic acids research, 49(D1), D562-D569. Oxford University Press |
| ISSN: | 0305-1048 |
| DOI: | 10.1093/nar/gkaa895 |
| Popis: | Kinases are a prime target of drug development efforts with >60 drug approvals in the past two decades. Due to the research into this protein family, a wealth of data has been accumulated that keeps on growing. KLIFS—Kinase–Ligand Interaction Fingerprints and Structures—is a structural database focusing on how kinase inhibitors interact with their targets. The aim of KLIFS is to support (structure-based) kinase research through the systematic collection, annotation, and processing of kinase structures. Now, 5 years after releasing the initial KLIFS website, the database has undergone a complete overhaul with a new website, new logo, and new functionalities. In this article, we start by looking back at how KLIFS has been used by the research community, followed by a description of the renewed KLIFS, and conclude with showcasing the functionalities of KLIFS. Major changes include the integration of approved drugs and inhibitors in clinical trials, extension of the coverage to atypical kinases, and a RESTful API for programmatic access. KLIFS is available at the new domain https://klifs.net. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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