Development of Electrospun Chitosan-Polyethylene Oxide/Fibrinogen Biocomposite for Potential Wound Healing Applications
| Autor: | Monica C Johnson, Tony T Yuan, Jonathan M. Stahl, Ann Marie DiGeorge Foushee, Angela R. Jockheck-Clark |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Scaffold
Materials science medicine.medical_treatment Nanofibers Wound healing 02 engineering and technology 010402 general chemistry 01 natural sciences Fibroblast migration Chitosan chemistry.chemical_compound medicine lcsh:TA401-492 General Materials Science Nano Express Electrospinning Growth factor Fibrinogen PDGF 021001 nanoscience & nanotechnology Condensed Matter Physics 0104 chemical sciences Biomedical applications chemistry Nanofiber Wound dressing lcsh:Materials of engineering and construction. Mechanics of materials Biocomposite 0210 nano-technology Biomedical engineering |
| Zdroj: | Nanoscale Research Letters, Vol 13, Iss 1, Pp 1-12 (2018) Nanoscale Research Letters |
| ISSN: | 1931-7573 |
| Popis: | Normal wound healing is a highly complex process that requires the interplay of various growth factors and cell types. Despite advancements in biomaterials, only a few bioactive wound dressings reach the clinical setting. The purpose of this research was to explore the feasibility of electrospinning a novel nanofibrous chitosan (CS)-fibrinogen (Fb) scaffold capable of sustained release of platelet-derived growth factor (PDGF) for the promotion of fibroblast migration and wound healing. CS-Fb scaffolds were successfully electrospun using a dual-spinneret electrospinner and directly evaluated for their physical, chemical, and biological characteristics. CS-polyethylene/Fb scaffolds exhibited thinner fiber diameters than nanofibers electrospun from the individual components while demonstrating adequate mechanical properties and homogeneous polymer distribution. In addition, the scaffold demonstrated acceptable water transfer rates for wound healing applications. PDGF was successfully incorporated in the scaffold and maintained functional activity throughout the electrospinning process. Furthermore, released PDGF was effective at promoting fibroblast migration equivalent to a single 50 ng/mL dose of PDGF. The current study demonstrates that PDGF-loaded CS-Fb nanofibrous scaffolds possess characteristics that would be highly beneficial as novel bioactive dressings for enhancement of wound healing. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink