Nosocomial Outbreak of Cross-Infection due to Multiple-Antibiotic-Resistant Klebsiella pneumoniae: Characterization of the Strain and Antibiotic Susceptibility Studies
| Autor: | Walter H. Traub, Isabel Schwarze, Dierk Bauer |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Cross infection endocrine system Klebsiella pneumoniae medicine.drug_class Antibiotics Microbial Sensitivity Tests macromolecular substances beta-Lactam Resistance Disease Outbreaks Microbiology Antibiotic resistance Anti-Infective Agents Drug Discovery medicine Humans Pharmacology (medical) Antibacterial agent Pharmacology Cross Infection Nosocomial outbreak biology Strain (chemistry) Infant Newborn General Medicine biology.organism_classification Virology Drug Resistance Multiple Anti-Bacterial Agents Klebsiella Infections Infectious Diseases Carbapenems Oncology Polymyxin B Fluoroquinolones medicine.drug |
| Zdroj: | Chemotherapy. 46:1-14 |
| ISSN: | 1421-9794 0009-3157 |
| Popis: | A multiple-antibiotic-resistant (MAR) strain of Klebsiella pneumoniae was introduced into a pediatric ward and subsequently colonized neonates of two wards with several cases of systemic infection. This strain produced an extended-spectrum β-lactamase and was resistant to cefotaxime, ceftazidime, and, among others, all aminoglycosides including amikacin. The majority of representative isolates examined with macrorestriction analysis of genomic DNA (pulsed-field gel electrophoresis) were identical. The strain was susceptible to the innate antibacterial systems operative in fresh defibrinated blood from two adults. Combined human blood/antimicrobial drug assays documented the in vitro bactericidal activity of carbapenems (meropenem was slightly more effective than imipenem), fluoroquinolones (ciprofloxacin and trovafloxacin), and polymyxin B against this MAR strain of K. pneumoniae. |
| Databáze: | OpenAIRE |
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