Treatment strategies for HIV-infected patients with tuberculosis: ongoing and planned clinical trials
| Autor: | Philip Chukwuka Onyebujoh, Diane V. Havlir, François-Xavier Blanc, Anne E. Goldfeld, Sok Thim, Jean-François Delfraissy |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Pediatrics
medicine.medical_specialty Tuberculosis Anti-HIV Agents Population HIV Infections Southeast asian Global Health Drug Administration Schedule Acquired immunodeficiency syndrome (AIDS) Antiretroviral Therapy Highly Active Epidemiology medicine Immunology and Allergy Humans education education.field_of_study Clinical Trials as Topic business.industry International Agencies medicine.disease Clinical trial Regimen Infectious Diseases Immunology Acute Disease Coinfection HIV-1 business |
| Zdroj: | The Journal of infectious diseases. 196 |
| ISSN: | 0022-1899 |
| Popis: | Currently, there are limited data to guide the management of highly active antiretroviral therapy (HAART) for human immunodeficiency virus type 1 (HIV-1)-infected patients with active tuberculosis (TB), the leading cause of death among individuals with acquired immunodeficiency syndrome (AIDS) in resource-limited areas. Four trials to take place in Southeast Asian, African, and South American countries will address the unresolved question of the optimal timing for initiation of HAART in patients with AIDS and TB: (1) Cambodian Early versus Late Introduction of Antiretrovirals (CAMELIA [ANRS 1295/NIH-CIPRA KH001]), (2) Adult AIDS Clinical Trials Group A5221, (3) START, and (4) a trial sponsored by the World Health Organization/Special Programme for Research and Training in Tropical Diseases. Two other clinical questions regarding patients with TB and HIV-1 coinfection are also undergoing evaluation: (1) the benefits of short-term HAART when CD4 cell counts are >350 cells/mm(3) (PART [NIH 1 R01 AI051219-01A2]) and (2) the efficacy of a once-daily HAART regimen in treatment-naive patients (BKVIR [ANRS 129]). Here, we present an overview of these ongoing or planned clinical studies, which are supported by international agencies. |
| Databáze: | OpenAIRE |
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