Severe cutaneous adverse drug reactions: A clinicoepidemiological study
| Autor: | Uma Rajan, Sarita Sasidharanpillai, Deepthi N Sureshan, Anza Khader, Manikoth Payyanadan Binitha, Najeeba Riyaz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
education.field_of_study
medicine.medical_specialty Pediatrics business.industry Cross-sectional study Mortality rate Population drug reaction with eosinophilia and systemic symptoms complex Dermatology lcsh:RL1-803 Acute generalized exanthematous pustulosis medicine.disease E-IJD Original Article Toxic epidermal necrolysis Drug reaction Epidemiology medicine lcsh:Dermatology Population study epidemiology education business Adverse effect |
| Zdroj: | Indian Journal of Dermatology, Vol 60, Iss 1, Pp 102-102 (2015) Indian Journal of Dermatology |
| ISSN: | 1998-3611 0019-5154 |
| Popis: | Background: Drug eruptions range from transient erythema to the life threatening severe cutaneous adverse reactions (SCAR) that encompass Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP) and drug reaction with eosinophilia and systemic symptoms complex (DRESS). Aims and Objectives: To study the clinical and epidemiological aspects of cutaneous adverse drug reactions (CADR). Materials and Methods: Ethical clearance was obtained from the institutional ethics committee. All patients admitted in the Dermatology ward of our tertiary care hospital with CADR (those who fit in the category of probable or possible drug reaction as per WHO casuality assessment) from first September 2011 to 31 st August 2012 were included in this cross sectional study after obtaining written informed consent. The drug reaction patterns observed in the study population were determined and the common offending drugs were identified. Results: In the study, population of males outnumbered females and the majority were between 46 and 60 years of age. The commonest reaction pattern observed was SJS- TEN spectrum of illness and aromatic anticonvulsants were the common offending drugs. Prompt withdrawal of the culprit drug and administration of systemic steroids with or without I/V Ig reverted the adverse reaction in all except one. Conclusion: Severe drug reactions predominated as the study population was comprised of inpatients of a tertiary referral centre. Though; previous authors had reported a mortality rate of up to 20% in DRESS, all our patients with this reaction pattern, responded well to treatment. The mortality rate among TEN cases was much lower than the previous reports. Early diagnosis, prompt withdrawal of the suspected drug, careful monitoring for development of complications and immediate intervention can improve the prognosis of CADR. |
| Databáze: | OpenAIRE |
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