HCV Extrahepatic Manifestations
| Autor: | Jelena Jakab, George Y. Wu, Martina Smolić, Robert Smolić, Lucija Kuna |
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| Rok vydání: | 2019 |
| Předmět: |
TGF-β-dependent signaling pathway
Hepatitis C virus Review Article Type 2 diabetes Direct-acting antivirals medicine.disease_cause Virological response Insulin resistance medicine Hepatic stellate cells B cell lymphomas Keywords: Hepatitis C virus Hepatic stellate cells B cell lymphomas pancreatic B cell TGF-β-dependent signaling pathway Extrahepatic manifestations Direct-acting antivirals Hepatology business.industry Antiviral therapy virus diseases medicine.disease Cryoglobulinemia digestive system diseases Lymphoma Immunology Hepatic stellate cell Extrahepatic manifestations business pancreatic B cell |
| Zdroj: | Journal of Clinical and Translational Hepatology |
| ISSN: | 2310-8819 2225-0719 |
| DOI: | 10.14218/jcth.2018.00049 |
| Popis: | Hepatitis C virus (HCV) has been shown to affect many tissues other than liver. However, of the many extrahepatic manifestations (EMs) that have been associated with HCV, including cryoglobulinemia, lymphoma, insulin resistance, type 2 diabetes and neurological disorders, only a few have been shown to be directly related to HCV infection of extrahepatic tissues. HCV-triggered immune- mediated mechanisms account for most of the EMs. It is estimated that up to 74% of patients with chronic hepatitis C can develop at least one EM. All HCV patients with EMs should be considered for antiviral therapy, although not all will resolve with sustained virological response. |
| Databáze: | OpenAIRE |
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