Terpinen-4-ol and nystatin co-loaded precursor of liquid crystalline system for topical treatment of oral candidiasis
| Autor: | Patricia Milagros Maquera-Huacho, Renata Serignoli Francisconi, Caroline Coradi Tonon, Giovana Maria Fioramonti Calixto, Denise Madalena Palomari Spolidorio, Janaina de Cássia Orlandi Sardi, Marlus Chorilli |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp), Universidade Estadual de Campinas (UNICAMP) |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Nystatin Antifungal Agents 030106 microbiology lcsh:Medicine 02 engineering and technology Article Chitosan 03 medical and health sciences chemistry.chemical_compound Minimum inhibitory concentration Candidiasis Oral Candida albicans medicine Mucoadhesion Humans lcsh:Science Multidisciplinary Chromatography biology Cetyl alcohol Terpenes lcsh:R Fungi 021001 nanoscience & nanotechnology biology.organism_classification Corpus albicans Oleic acid chemistry Biofilms lcsh:Q 0210 nano-technology medicine.drug |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020) Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 2045-2322 |
| Popis: | Made available in DSpace on 2020-12-12T02:17:23Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-12-01 This study was performed to develop a liquid crystalline system (LCS) incorporated with terpinen-4-ol and nystatin to evaluate its antifungal, antibiofilm, and synergistic/modulatory activity against Candida albicans. The LCS was composed of a dispersion containing 40% propoxylated and ethoxylated cetyl alcohol, 40% oleic acid, and 0.5% chitosan dispersion. According to analysis by polarized light microscopy, rheology, and mucoadhesion studies, the incorporation of 100% artificial saliva increased the pseudoplasticity, consistency index, viscosity, and mucoadhesion of the formulation. The minimum inhibitory concentration, minimum fungicidal concentration, and rate of biofilm development were used to evaluate antifungal activity; the LCS containing terpinen-4-ol and nystatin effectively inhibited C. albicans growth at a lower concentration, displaying a synergistic action. Therefore, LCS incorporated with terpinen-4-ol and nystatin is a promising alternative for preventing and treating infections and shows potential for the development of therapeutic strategies against candidiasis. Department of Physiology and Pathology School of Dentistry of Araraquara Universidade Estadual Paulista UNESP Department of Drugs and Medicines School of Pharmaceutical of Araraquara UNESP Department of Physiological Sciences School of Dentistry of Piracicaba UNICAMP Department of Physiology and Pathology School of Dentistry of Araraquara Universidade Estadual Paulista UNESP Department of Drugs and Medicines School of Pharmaceutical of Araraquara UNESP |
| Databáze: | OpenAIRE |
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