Pregnancy-induced morphologic changes in lymphocytes; an experimental study on materno-fetal tolerance in the rat
| Autor: | V. Knobloch, Z. Krabec, V. Jouja |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Pathology
medicine.medical_specialty Nucleolus Lymphocyte Normal pregnancy Andrology Antigen Pregnancy Immune Tolerance medicine Animals Humans Lymphocytes skin and connective tissue diseases Maternal-Fetal Exchange Fetus business.industry Obstetrics and Gynecology Rats Inbred Strains medicine.disease Rats medicine.anatomical_structure Reproductive Medicine Pregnancy induced Female sense organs business Cell Nucleolus |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 9:391-397 |
| ISSN: | 0301-2115 |
| Popis: | Morphological changes in lymphocyte nucleoli were examined in the course of pregnancy in rats. Small amounts of lymphocytes became activated, most of them producing micronucleoli. These findings show the same changes as found in the course of pregnancy in women. Subcutaneous administration of human placental eluate to non-pregnant rats induced a low degree of activation and high micronucleoli formation, dependent on the dose of placental antigen. Repeated administration of increasing doses of placental eluate revealed almost the same morphological changes in lymphocyte nucleoli as seen in normal pregnancy. This is considered an experimental verification that the morphological changes in lymphocyte nucleoli during pregnancy are due to permanent and gradually increasing doses of foreign antigen. |
| Databáze: | OpenAIRE |
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