Effect of chronic furosemide administration on hydrogen and sodium excretion in the dog
| Autor: | T Kahn, M. F. Levitt, J. P. Bosch, MH Goldstein |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
medicine.medical_specialty
Alkalosis Physiology Natriuresis Electrolyte Hematocrit Plasma renin activity Drug Administration Schedule Excretion Electrolytes chemistry.chemical_compound Dogs Chlorides Furosemide Internal medicine Renin medicine Animals Acid-Base Equilibrium Creatinine medicine.diagnostic_test Body Weight Adrenalectomy Liter Hydrogen-Ion Concentration medicine.disease Diet Bicarbonates Endocrinology chemistry Potassium medicine.drug |
| Zdroj: | American Journal of Physiology-Renal Physiology. 232:F397-F404 |
| ISSN: | 1522-1466 1931-857X |
| DOI: | 10.1152/ajprenal.1977.232.5.f397 |
| Popis: | Studies were performed to evaluate the effects of the chronic administration of furosemide on hydrogen and electrolyte excretion in dogs on a normal electrolyte diet and in the absence of electrolyte or volume depletion. Control daily excretion in five dogs averaged 64 meq for Na, 51 meq for K, 66 meq for Cl, and 17 meq for net H. Furosemide, 40 mg, in the drinking water 3 times daily was given for 4 days. On day 1 Na excretion averaged 128 meq, but thereafter was not significantly different from control levels. Over 4 days cumulative net H excretion increased 63.6 meq and plasma HCO3 rose 6.6 meq/liter. The same dogs were restudied by the same protocol except that, to obviate electrolyte depletion, NaCl and KCl were administered daily in quantities sufficient to replace urinary losses. All dogs remained in positive Na, K, and Cl balance. Body weight, hematocrit, plasma albumin, creatinine, and plasma renin activity were unchanged, indicating the absence of electrolyte or volume depletion. Nonetheless, cumulative net H excretion increased 61.2 meq and plasma HCO3 increased 4.3 meq/liter. Two adrenalectomized dogs receiving steroid replacement showed similar changes in net H excretion and plasma HCO3. These experiments suggest that chronic furosemide administration may enhance H excretion and generate alkalosis even in the absence of volume or electrolyte depletion and without increased aldosterone secretion. |
| Databáze: | OpenAIRE |
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