Somatostatin receptor 1,2 and 5 activation leads to C6 glioma growth arrest in vitro and in vivo; analysis of the intracellular pathways involved
| Autor: | Monica Gatti, Alessandra Pattarozzi, Federica Barbieri, Tullio Florio, Francesca Angeletti, Roberto Würth |
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| Rok vydání: | 2011 |
| Předmět: |
Agonist
medicine.medical_specialty medicine.drug_class Biochemistry (medical) Plant Science Biology General Biochemistry Genetics and Molecular Biology In vitro Endocrinology Somatostatin lcsh:Biology (General) Internal medicine Cancer research Somatostatin receptor 3 medicine Somatostatin receptor 2 Somatostatin receptor 1 Receptor lcsh:QH301-705.5 somatostatin somatostatine receptor gliomas Intracellular |
| Zdroj: | Journal of Biological Research, Vol 84, Iss 1 (2011) |
| ISSN: | 2284-0230 1826-8838 |
| DOI: | 10.4081/jbr.2011.4649 |
| Popis: | We report that somatostain receptor (SSTR) 1,2 and 5 activation by selective agonista, cause C6 cell growth arrest through PTPn-dependent dephosphorylation of ERK1/2 in vitro and after xenografting in nude mice. Individual SSTR agonist desplayed different efficacy and potecy showing partial synergism by combined treatment. Since most tumor cells express multiple SSTRs, the activtion of all the subtypes may grant a better control of cancer growth. |
| Databáze: | OpenAIRE |
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