Neonatal fatty acid status and cardiometabolic health at 9years

Autor: Hedwig K. Kikkert, Günther Boehm, Corina de Jong, Tamás Decsi, Jorien Seggers, Mijna Hadders-Algra
Přispěvatelé: Extremities Pain and Disability (EXPAND), Groningen Research Institute for Asthma and COPD (GRIAC)
Rok vydání: 2016
Předmět:
0301 basic medicine
Umbilical Veins
Anthropometrics
Health Status
OIL SUPPLEMENTATION
BLOOD-PRESSURE
Blood Pressure
MATERNAL FISH
Umbilical cord
Umbilical Arteries
chemistry.chemical_compound
0302 clinical medicine
Diastole
Heart Rate
Medicine
Child
chemistry.chemical_classification
Adipogenesis
Arachidonic Acid
Anthropometry
Obstetrics and Gynecology
RANDOMIZED CONTROLLED-TRIAL
Fetal Blood
Eicosapentaenoic acid
DHA
medicine.anatomical_structure
Docosahexaenoic acid
GROWTH
Arachidonic acid
TERM INFANTS
Polyunsaturated fatty acid
medicine.medical_specialty
BODY-COMPOSITION
Docosahexaenoic Acids
03 medical and health sciences
PRETERM INFANTS
030225 pediatrics
Internal medicine
Heart rate
Humans
LCPUFA
030109 nutrition & dietetics
business.industry
Infant
Newborn
AA
DHA STATUS
Blood pressure
Endocrinology
chemistry
Pediatrics
Perinatology and Child Health
FOLLOW-UP
business
Body mass index
Follow-Up Studies
Zdroj: Early Human Development, 100, 55-59. ELSEVIER IRELAND LTD
ISSN: 0378-3782
DOI: 10.1016/j.earlhumdev.2016.05.008
Popis: Background: Long chain polyunsaturated fatty acid (LCPUFA) status is associated with risk of cardiovascular diseases in adulthood. We previously demonstrated no effect of LCPUFA supplementation after birth on BP and anthropometrics. Little is known about the association between fatty acid status at birth and cardiometabolic health at older ages.Aim: To evaluate associations between docosahexaenoic acid (DHA) and arachidonic acid (AA) levels in the umbilical cord and blood pressure (BP) and anthropometrics at 9 years.Study design: Observational follow-up study. Multivariable analyses were carried out to adjust for potential confounders.Subjects: 229 children who took part in a randomized controlled trial (RCT) on the effects of LCPUFA formula supplementation.Outcome measures: BP was chosen as primary outcome; heart rate and anthropometrics as secondary outcomes.Results: AA levels in the wall of the umbilical vein and artery were negatively associated with diastolic BP (B: vein -0.831, 95% CI: -1.578; -0.083, p = 0.030; artery: -0.605, 95% CI: -1.200; -0.010, p = 0.046). AA was not associated with systolic BP; DHA not with diastolic nor systolic BP. The AA:DHA ratio in the umbilical vein was negatively associated with diastolic BP (B: -1.738, 95% CI: -3.141; -0.335, p = 0.015). Heart rate and anthropometrics were not associated with neonatal LCPUFA status.Conclusions: Higher AA levels and a higher AA:DHA ratio at birth are associated with lower diastolic BP at age 9. This suggests that the effect of LCPUFAs at early age is different from that in adults, where DHA is regarded antiadipogenic and AA as adipogenic. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
Databáze: OpenAIRE
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