Eruption of lymphocyte recovery or autologous graft-versus-host disease?
| Autor: | Ruud G. L. Nellen, Pamela Poblete-Gutiérrez, Peter M. Steijlen, Jorge Frank, Arienne M. W. Van Marion |
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| Rok vydání: | 2008 |
| Předmět: |
Biopsy
medicine.medical_treatment Lymphocyte Graft vs Host Disease Dermatology Engraftment Syndrome Hematopoietic stem cell transplantation Disease Skin Diseases Pathogenesis Autologous stem-cell transplantation immune system diseases medicine Humans Lymphocytes Multiple myeloma Skin business.industry Hematopoietic Stem Cell Transplantation Middle Aged medicine.disease Transplantation surgical procedures operative medicine.anatomical_structure Immunology Female Multiple Myeloma business |
| Zdroj: | International Journal of Dermatology. 47:32-34 |
| ISSN: | 1365-4632 0011-9059 |
| DOI: | 10.1111/j.1365-4632.2008.03956.x |
| Popis: | Maculopapular exanthemas have a particular high incidence among patients treated with autologous hematopoietic stem cell transplantation (HSCT). In most cases, a viral or drug induced origin is easily identified. However, the transplantation itself may also induce similar skin changes. These exanthemas are known under various names, such as autologous graft-versus-host disease (GVHD), engraftment syndrome (ES) or eruption of lymphocyte recovery (ELR). Given the clinical and histopathological similarities of these disorders, it can prove difficult to establish a diagnosis. Here, we describe a patient who developed a maculopapular exanthema after autologous stem cell transplantation for multiple myeloma, diagnosed as autologous GVHD. We also briefly review the current knowledge of the pathogenesis of autologous GVHD, ES, and ELR. Based on these data we would like to suggest that the latter two do not reflect own disease entities but rather different presentations of autologous GVHD. |
| Databáze: | OpenAIRE |
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