Phase I and pharmacokinetic evaluation of the anti-telomerase agent KML-001 with cisplatin in advanced solid tumors
| Autor: | Jan H. Beumer, Jogarao Gobbru, Josephine Feliciano, Martin J. Edelman, Tao Liu, Miroslav Styblo, Rena G. Lapidus |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Cancer Research medicine.medical_specialty Arsenites Endpoint Determination Nausea Antineoplastic Agents Pharmacology Toxicology Gastroenterology Arsenic 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pharmacokinetics Neoplasms Internal medicine Antineoplastic Combined Chemotherapy Protocols Clinical endpoint medicine Humans Pharmacology (medical) Enzyme Inhibitors Telomerase Aged Platinum Cisplatin business.industry Middle Aged Sodium Compounds Carboplatin Long QT Syndrome Treatment Outcome 030104 developmental biology Oncology chemistry Tolerability 030220 oncology & carcinogenesis Toxicity Vomiting Female medicine.symptom business medicine.drug |
| Zdroj: | Cancer Chemotherapy and Pharmacology. 78:959-967 |
| ISSN: | 1432-0843 0344-5704 |
| Popis: | KML-001 (sodium metaarsenite) displaces hTERT from the nucleus and is synergistic with cisplatin. This phase I trial tested the tolerability, activity and pharmacology of this combination. Patients with advanced solid tumors that were “platinum sensitive,” PS 0-1, normal renal and hepatic function were eligible. Treatment was with cisplatin 75 mg/m2 day 1 and KML-001 p.o. daily days 1–14 on a 21-day cycle. A standard 3 + 3 design was employed. Blood specimens for arsenic and platinum pharmacokinetics were obtained at 0, 1, 2, 3, 4, 5, 6, 24 h and days 8, 15 and 22. Eighteen patients (7 M, 11 F) were evaluable for the primary endpoint of toxicity. Patients were heavily pretreated for a variety of malignancies (mean number of prior regimens = 3). Sixteen had prior platinum therapy. The dose-limiting toxicity was prolongation of the QTc interval, seen in three patients in cohort 3 (20 mg) (two during cycle 1, one during cycle 2). A documented response was seen in a patient with heavily pretreated SCLC in cohort one. Several other patients had reduction in tumor burden. In addition to the dose-limiting toxicity of QTc prolongation, the most common toxicities observed were nausea and vomiting and cytopenias. Myelosuppression was primarily seen in patients who had undergone prior radiotherapy. The combination of KML-001 and cisplatin was technically feasible and active. However, the occurrence of significant QTc prolongation led to discontinuation of the trial. This prolongation was likely a result of electrolyte abnormalities resulting from cisplatin superimposed on the known risks of arsenicals and QTc prolongation. Combinations with other platinum agents (e.g., carboplatin) should be considered. This is the first fully reported human trial of KML-001. |
| Databáze: | OpenAIRE |
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