Risk of stroke among patients with borderline personality disorder: A nationwide longitudinal study
| Autor: | Wen Han Chang, Kai Lin Huang, Mu Hong Chen, Ya Mei Bai, Shih-Jen Tsai, Cheng Ta Li, Tung Ping Su, Wei Chen Lin, Tzeng Ji Chen, Ju Wei Hsu |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Longitudinal study medicine.medical_specialty Databases Factual National Health Programs Taiwan 03 medical and health sciences 0302 clinical medicine Borderline Personality Disorder Risk Factors Diabetes mellitus Internal medicine mental disorders medicine Humans Longitudinal Studies Borderline personality disorder Stroke Aged Proportional Hazards Models Proportional hazards model Middle Aged medicine.disease 030227 psychiatry Psychiatry and Mental health Clinical Psychology Increased risk National health insurance Case-Control Studies Physical therapy Regression Analysis Female Psychology 030217 neurology & neurosurgery Dyslipidemia |
| Zdroj: | Journal of affective disorders. 219 |
| ISSN: | 1573-2517 |
| Popis: | Background Previous studies suggested that patients with borderline personality disorder (BPD) had a higher prevalence of stroke-related risk factors, such as hypertension, dyslipidemia, and diabetes mellitus. But, the association between BPD and subsequent stroke has been rarely investigated. Methods Using the Taiwan National Health Insurance Research Database, 5969 borderline patients aged 18 years and older and 23,876 age-and sex-matched controls were enrolled between 2002 and 2009, and followed up to the end of 2011 to identify the development of stroke. Results The Cox regression model after adjusting for demographic data, psychiatric comorbidities, and medical comorbidities showed that BPD was associated with an increased risk of developing any stroke (HR: 4.82, 95% CI: 2.77–8.40) and ischemic stroke (HR: 5.67, 95% CI: 2.49–12.93). The findings of sensitivity analysis after excluding the first year of observation were consistent: any stroke (HR: 3.44, 95% CI: 1.83–6.47) and ischemic stroke (HR: 4.75, 95% CI: 1.91–11.77). Discussion Patients with BPD had an elevated vulnerability to subsequent stroke and ischemic stroke compared to those without BPD. Further studies would be required to investigate the underlying mechanisms. |
| Databáze: | OpenAIRE |
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