Early Detection of Desiccation and Curettage Failure in the Treatment of Basal Cell Carcinoma
| Autor: | Adam B. Woldow, Megan E. Melvin |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Skin Neoplasms Additional Therapy medicine.medical_treatment Early detection Dermatology Single Center Curettage 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine Humans Basal cell carcinoma Treatment Failure Desiccation skin and connective tissue diseases Pathological Early Detection of Cancer integumentary system business.industry medicine.disease Immunohistochemistry Surgery Carcinoma Basal Cell 030220 oncology & carcinogenesis Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Dermatology. 232:696-699 |
| ISSN: | 1421-9832 1018-8665 |
| Popis: | Background/Aims: Basal cell carcinoma (BCC) is a malignant neoplasm of keratinocytes. Electrodessication and curettage (ED&C) published cure rates vary widely, and the authors of this study are unaware of any previous literature which has attempted to rapidly identify treatment failures. Objective: To identify BCC ED&C failures by histologically analyzing the fragments produced by the third round of curettage. Methods: The monitoring of routine therapy of 862 cases of BCC that were treated by ED&C followed by the submission of cautery fragments of the third round of curettage for histological and immunohistochemical testing. Results: Of the 862 cases, 764 (89%) had no residual BCC seen in their curetting. Of these patients, zero recurrences (0%) were noted. Forty-eight of the 862 cases had residual BCC seen in their curetting and elected to receive no additional therapy. Eighteen (38%) had a recurrence detected. Fifty of the 862 cases had residual BCC seen in their curetting and elected for immediate re-excision. Thirty-five (70%) had histological evidence of residual BCC. Limitations: The study was performed at a single center with 2 years of follow-up. Conclusion: Pathological examination of curettage fragments in combination with immunohistochemistry testing appears to be beneficial in predicting which patients are likely to have recurrence of BCC after ED&C. |
| Databáze: | OpenAIRE |
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