Treatment outcomes of sinonasal adenoid cystic carcinoma: 30 cases from a single institution
| Autor: | Sang Yeob Seong, Chang Hoon Kim, Joo-Heon Yoon, Hyung Ju Cho, Dong Woo Hyun, Yoo Suk Kim, Jeung Gweon Lee |
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| Rok vydání: | 2013 |
| Předmět: |
Nasal cavity
Adult Male medicine.medical_specialty Maxillary sinus Adenoid cystic carcinoma Maxillary Sinus Neoplasms Treatment outcome Nose Neoplasms Postoperative radiotherapy Disease Disease-Free Survival medicine Humans Neoplasm Invasiveness Single institution Stage (cooking) Early Detection of Cancer Aged Neoplasm Staging Retrospective Studies business.industry Middle Aged medicine.disease Prognosis Carcinoma Adenoid Cystic Surgery Survival Rate medicine.anatomical_structure Treatment Outcome Otorhinolaryngology Female Radiotherapy Adjuvant Oral Surgery Nasal Cavity Neoplasm Recurrence Local business Paranasal Sinus Neoplasms Follow-Up Studies |
| Zdroj: | Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery. 42(5) |
| ISSN: | 1878-4119 |
| Popis: | Objective To establish the clinical features and prognostic factors of sinonasal adenoid cystic carcinoma (ACC). Material and methods Thirty patients with histopathological diagnosis of sinonasal ACC who were treated at Severance Hospital between 1990 and 2010 were included in this retrospective chart review study. Results The 5-year disease-specific survival and disease-free survival rates were 75.3% and 37.2%, respectively. The maxillary sinus (63.3%) and nasal cavity (23.3%) were the most common sites of primary tumour. Most patients were diagnosed with advanced-stage (III/IV) disease (80.0%) and had undergone surgery and postoperative radiotherapy (70.0%). The most common histopathological subtype was cribriform type (40.9%). Local recurrence rate and distant metastasis rates were 26.7% and 23.3%, respectively. The mean time from primary treatment to recurrence was 44.5 months. Sinonasal ACC patients with stage IV and T4 disease had significantly worse survival than those with low stage and T disease. Patients with local recurrence had worse disease-specific survival than those with distant recurrence. Distant metastasis was associated with disease-free survival but not disease-specific survival. Conclusion Despite the frequent occurrence of distant metastasis, early diagnosis and effective local control seemed to be the most important factors influencing the survival of sinonasal ACC. |
| Databáze: | OpenAIRE |
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