Testosterone substitution of hypogonadal men prevents the age-dependent increases in body mass index, body fat and leptin seen in healthy ageing men: results of a cross-sectional study
| Autor: | Eberhard Nieschlag, U Koken, C. Rolf, S von Eckardstein |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Leptin Male Aging medicine.medical_specialty Cross-sectional study Endocrinology Diabetes and Metabolism Body weight Chorionic Gonadotropin Body Mass Index Fat mass Endocrinology Reference Values Internal medicine Humans Medicine Testosterone Gonadal Steroid Hormones Aged business.industry Hypogonadism Testosterone (patch) Kallmann Syndrome General Medicine Middle Aged Cross-Sectional Studies Adipose Tissue Ageing business Body mass index Hormone |
| Zdroj: | European Journal of Endocrinology. :505-511 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje.0.1460505 |
| Popis: | Introduction: In healthy men, body weight and total fat content increase with advancing age, while serum testosterone levels decrease. In order to elucidate whether a causal relationship between these phenomena exists, we investigated the influence of testosterone or human chorionic gonadotrophin substitution on body mass index (BMI), total fat mass and serum leptin in testosterone-treated and untreated hypogonadal patients in comparison with ageing eugonadal men. Methods: In a cross-sectional study, the inter-relationships of body weight, total fat mass, serum sex hormones and leptin were analysed in untreated hypogonadal men (na 24; age 19 ‐ 65 years), treated hypogonadal men (na 61; age 20 ‐ 67 years) and healthy eugonadal men (na 60; age 24 ‐ 78 years). Total fat mass was assessed by bioimpedance measurement. Univariate and multiple linear regression analysis was used to detect possible differences. Results: In eugonadal men, serum testosterone levels decreased with advancing age (correlation coefficents: ra 20:71; P , 0:0001), while BMI Ora 0:39; Pa 0:002U; total fat content Ora 0:51; P , 0:0001U and leptin Ora 0:48; P , 0:0001U increased significantly. In untreated hypogonadal patients, an increase in BMI Ora 0:50; Pa 0:013U and total fat mass Ora 0:41; Pa 0:044U was also observed with advancing age. However, in substituted hypogonadal patients, no age-dependent change in BMI Ora 0:067; Pa 0:606U; body fat content Ora 20:083; Pa 0:522U; serum testosteroneOra 20; 071; Pa 0:59U or serum leptinOra 20:23; Pa 0:176U was found. Conclusion: Since testosterone-substituted older hypogonadal men show BMI and fat mass similar to those of younger eugonadal men and since non-treated hypogonadal men are similar to normal ageing men, testosterone appears to be an important factor contributing to these changes. Thus ageing men should benefit from testosterone substitution as far as body composition is concerned. |
| Databáze: | OpenAIRE |
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