Donor levels of serum alanine aminotransferase activity and antibody to hepatitis B core antigen associated with recipient hepatitis C and non-B, non-C outcomes
| Autor: | Luiz H. Barbosa, F B Hollinger, W. Huang, George J. Nemo, Cladd E. Stevens, D.O. Stram, J W Mosley, R D Aach, Marek Nowicki |
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| Rok vydání: | 2003 |
| Předmět: |
Hepatitis C virus
Immunology Blood Donors medicine.disease_cause Flaviviridae medicine Humans Immunology and Allergy Seroconversion Hepatitis biology business.industry Transfusion Reaction virus diseases Alanine Transaminase Hematology Hepatitis C Hepatitis B medicine.disease biology.organism_classification Hepatitis B Core Antigens digestive system diseases Alanine transaminase Multivariate Analysis biology.protein Antibody business |
| Zdroj: | Transfusion. 36:776-781 |
| ISSN: | 0041-1132 |
| DOI: | 10.1046/j.1537-2995.1996.36996420752.x |
| Popis: | Background: Hepatitis virus(es) that are neither hepatitis B (HBV) nor hepatitis C (HCV) (non-B, non-C [NBNC]) may be transmitted by transfusion. The present study assessed donor values for alanine aminotransferase (ALT) and antibody to hepatitis B core antigen (anti-HBc) for their association with HCV and NBNC hepatitis outcomes among allogeneic blood recipients. Study Design and Methods: Data on blood donors and recipients enrolled in the Transfusion-Transmitted Viruses Study in four United States cities from 1974 through 1980 were supplemented by anti-HBc testing of donors and anti-HCV evaluation of recipients. Two statistical approaches estimated the value of these indirect tests in detecting donors associated with HCV seroconversion and NBNC hepatitis in recipients. Results: For HCV cases, donor ALT alone (at ≥ 60 IU/L) had a sensitivity and a specificity of 30 and 96 percent, respectively, and anti-HBc alone (at ≥ 60% inhibition) had a sensitivity and specificity of 53 and 86 percent, respectively. The two markers combined had a sensitivity and a specificity of 69 and 83 percent. For NBNC hepatitis cases, each measure had low sensitivity (20%) that was not improved by using both (28%) [corrected]. Conclusion: The indirect tests proved to be equal in sensitivity to the first-generation anti-HCV tests. The positive predictive power of these indirect tests in the 1980s was sufficient to affect HCV incidence in studies during that period. Improved anti-HCV assays, however, replaced the need for indirect tests. The sensitivity of indirect tests for NBNC hepatitis contributed little. |
| Databáze: | OpenAIRE |
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