Hepatitis with bridging fibrosis and reversible hepatic insufficiency in a woman with rheumatoid arthritis taking methotrexate
| Autor: | Gregory Kujala, James E. Brick, J. M. Shamma'A, W. L. Chang |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Liver Cirrhosis
musculoskeletal diseases Piecemeal necrosis medicine.medical_specialty Immunology Arthritis Gastroenterology Hepatitis Arthritis Rheumatoid Necrosis Rheumatology Internal medicine Ascites medicine Humans Immunology and Allergy Pharmacology (medical) skin and connective tissue diseases medicine.diagnostic_test business.industry Liver Diseases Middle Aged medicine.disease Surgery Discontinuation Methotrexate Liver biopsy Rheumatoid arthritis Female medicine.symptom business medicine.drug |
| Zdroj: | Arthritis & Rheumatism. 33:1037-1041 |
| ISSN: | 1529-0131 0004-3591 |
| DOI: | 10.1002/art.1780330717 |
| Popis: | A patient with seropositive rheumatoid arthritis developed ascites while taking weekly doses of methotrexate (MTX). Her serum transaminase and albumin levels were normal. A liver biopsy revealed chronic hepatitis with bridging fibrosis and piecemeal necrosis. Upon discontinuation of MTX, her ascites resolved, and her arthritis became more active. This is the third report of reversible hepatic decompensation associated with prolonged MTX therapy in patients with rheumatoid arthritis. |
| Databáze: | OpenAIRE |
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