Defective leukocytotaxia and recurrent staphylococcal infecion: deficiency of leukocytotaxia and abnormal granulocytes associated with increase serum IgE levels in an adult with recurrent staphylococcal infection
| Autor: | Daniel Schmitt, Jeanne Leung-Tack, Michel Faure, René Jeune, Jean Thivolet |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
Neutrophils Phagocytosis Dermatology Immunoglobulin E In vivo Immunity Recurrence Hypergammaglobulinemia medicine Eosinophilia Humans Leukocytosis Aged biology business.industry Chemotaxis General Medicine Staphylococcal Infections Chemotaxis Leukocyte Increased serum IgE levels Immunology biology.protein medicine.symptom business Granulocytes |
| Zdroj: | Archives of Dermatology. 114:1372-1378 |
| ISSN: | 0003-987X |
| DOI: | 10.1001/archderm.114.9.1372 |
| Popis: | • A man who was suffering from recurrent staphylococcal infection had antecedent symptoms of severe pruritus. Laboratory investigations showed leukocytosis with eosinophilia, hyperimmunoglobulinemia of all fractions, but particularly of IgE, and a deficiency of cellmediated immunity on in vivo testing. Phagocytosis and bactericidal activity of polymorphonuclear leukocytes were normal, but a cellular and serum-associated defect in leukocytotaxia was present. Ultrastructural changes were observed in polymorphonuclear leukocytes. Association of impaired leukocytotaxia and elevated levels of IgE is not uncommon. Recurrent bacterial infections in the patient described are probably related to defective chemotaxis. ( Arch Dermatol 114:1372-1378, 1978) |
| Databáze: | OpenAIRE |
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