Effect of glucose concentration on activation of the ASK1-SEK1-JNK1 signal transduction pathway
| Autor: | Yong J. Lee, Jae J. Song |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty MAP Kinase Kinase 4 MAP Kinase Signaling System Genetic Vectors Immunoblotting Mitogen-activated protein kinase kinase Biology MAP Kinase Kinase Kinase 5 Biochemistry Adenoviridae Viral Proteins Thioredoxins Death-associated protein 6 Internal medicine Glutaredoxin Tumor Cells Cultured medicine Humans Mitogen-Activated Protein Kinase 8 ASK1 Molecular Biology Glutaredoxins Mitogen-Activated Protein Kinase Kinases MAP kinase kinase kinase Kinase Prostatic Neoplasms Proteins Cell Biology MAP Kinase Kinase Kinases TNF Receptor-Associated Factor 2 Cell biology Enzyme Activation Glucose Endocrinology Mitogen-Activated Protein Kinases Signal transduction Thioredoxin Oxidoreductases Dimerization |
| Zdroj: | Journal of Cellular Biochemistry. 89:653-662 |
| ISSN: | 1097-4644 0730-2312 |
| Popis: | Recently, acute total glucose deprivation has been shown to cause activation of ASK1-MEK-MAPK signal transduction and dissociation of glutaredoxin (GRX) from apoptosis signal-regulating kinase 1 (ASK1). In this study, we investigated whether clinically relevant concentrations (0.01-0.1 mM) of glucose promote ASK1 activation. We observed that a prominent activation of JNK1 occurred at a glucose concentration less than or equal to 0.01 mM. Similar to JNK1 activation, we also observed that low glucose-induced ASK1 activation, dissociation of GRX and thioredoxin (TRX) from ASK1, dimerization of ASK1, and association of Daxx and TRAF2 with ASK1 significantly occurred at a glucose concentration less than or equal to 0.01 mM. |
| Databáze: | OpenAIRE |
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