Autoimmune Gastrointestinal Dysmotility in a Patient With HIV Treated With Methylprednisolone and Pyridostigmine
| Autor: | Venkata R. Satyam, Mariana Albuquerque Machado, David Nunes, Christopher M. Gromisch |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
business.industry Autoantibody Human immunodeficiency virus (HIV) Dysautonomia Case Report General Medicine medicine.disease medicine.disease_cause Gastroenterology Pyridostigmine Methylprednisolone Internal medicine medicine Autoimmune gastrointestinal dysmotility medicine.symptom business Functional GI Disorders medicine.drug |
| Zdroj: | ACG Case Reports Journal |
| ISSN: | 2326-3253 |
| Popis: | Primary autoimmune gastrointestinal dysmotility is a limited form of autoimmune dysautonomia, driven by antiganglionic autoantibodies (AGAs) against enteric neurons. AGAs are observed in other autoimmune diseases, such as Guillain-Barré syndrome, before the development onset of gastrointestinal symptoms. Here, we report a case of a 57-year-old woman with human immunodeficiency virus, who previously developed Guillain-Barré syndrome, presenting with 6 months of intestinal dysmotility. Diagnosis was made by detecting AGAs to ganglionic acetylcholine receptor, alpha-3 subunit, radiographic evidence of duodenal dysmotility, and exclusion of other causes. The patient received high-dose methylprednisolone with low-dose pyridostigmine, which led to significant improvement of symptoms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|