Deep Brain Stimulation of the Pallidum is Effective and Might Stabilize Striatal D(2) Receptor Binding in Myoclonus-Dystonia
Autor: | Marina A. J. Tijssen, Johannes D. Speelman, Jan Booij, P.R. Schuurman, Richard J. Beukers, Maria Fiorella Contarino |
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Přispěvatelé: | Other departments, Amsterdam Neuroscience, Neurology, Neurosurgery, Nuclear Medicine |
Rok vydání: | 2011 |
Předmět: |
Striatal dopamine
congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Deep brain stimulation medicine.medical_treatment DBS Single-photon emission computed tomography Motor symptoms lcsh:RC346-429 Rating scale Internal medicine Dopamine receptor D2 medicine lcsh:Neurology. Diseases of the nervous system Original Research Dystonia medicine.diagnostic_test medicine.disease myoclonus nervous system diseases Endocrinology Neurology Neurology (clinical) dystonia medicine.symptom Psychology Myoclonus Neuroscience IBZM-SPECT |
Zdroj: | Frontiers in Neurology Frontiers in neurology, 3. Frontiers Media S.A. ResearcherID Frontiers in Neurology, Vol 3 (2012) |
ISSN: | 1664-2295 |
Popis: | Purpose: To assess clinical efficacy of deep brain stimulation of the pallidum in Myoclonus-Dystonia patients, and to compare pre- and postoperative striatal dopamine D2 receptor availability. Methods: Clinical parameters were scored using validated rating scales for myoclonus and dystonia. Dopamine D2 receptor binding of three patients was studied before surgery and approximately two years post-operatively using 123I-iodobenzamide Single Photon Emission Computed Tomography. Two patients who did not undergo surgery served as controls. Results: Clinically, the 3 Myoclonus-Dystonia patients improved 83%, 17% and 100%, respectively on the myoclonus rating scale and 78%, 23% and 65% on the dystonia rating scale after deep brain stimulation. Dopamine D2 receptor binding did not change after surgery. In the two control subjects, binding has lowered further. Conclusions: These findings confirm that deep brain stimulation of the pallidum has beneficial effects on motor symptoms in Myoclonus-Dystonia and suggest this procedure might stabilize dopamine D2 receptor binding. |
Databáze: | OpenAIRE |
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