Concentration Dependent Inhibition of Hepatic Gluconeogenesis by Insulin
| Autor: | C. D. Sladek, J. F. Snarr |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Alanine
medicine.medical_specialty Hepatic gluconeogenesis Dose-Response Relationship Drug Chemistry Insulin medicine.medical_treatment Gluconeogenesis Substrate (chemistry) General Biochemistry Genetics and Molecular Biology Rats Concentration dependent Endocrinology Internal medicine Rat liver medicine Animals Carbon Radioisotopes |
| Zdroj: | Experimental Biology and Medicine. 146:194-199 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-146-38068 |
| Popis: | SummaryThe rate of gluconeogenesis from Ul-14C-alanine was determined at physiological insulin concentrations in the isolated rat liver perfused with a non-recirculating medium. There was a significant negative relationship between gluconeogenesis and the insulin concentration over the range of 10-500 μU/ml. Increasing the insulin concentration to 1000 μU/ml did not result in any further reduction of gluconeogenesis. Insulin did not alter the gluconeogenic response of the liver to increasing substrate concentrations in these perfusions. |
| Databáze: | OpenAIRE |
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