Risk factors for graft loss in kidney transplant recipients with g3 glomerulitis: A single-center experience
| Autor: | Weixiong Zhong, Neetika Garg, Sandesh Parajuli, Arjang Djamali, Fahad Aziz, Maha Mohamed, Brenda Muth, Didier A. Mandelbrot, Thomas M. Ellis |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Basiliximab Renal function Single Center Gastroenterology chemistry.chemical_compound Young Adult Glomerulonephritis Prednisone Risk Factors Internal medicine Biopsy medicine Living Donors Humans Kidney transplantation Creatinine medicine.diagnostic_test business.industry Graft Survival Transplant glomerulopathy General Medicine Middle Aged medicine.disease Allografts Creatine Kidney Transplantation Kidney Tubules chemistry Nephrology Female business medicine.drug |
| Zdroj: | Clinical nephrology. 91(2) |
| ISSN: | 0301-0430 |
| Popis: | Background Risk factors for graft loss in kidney transplant recipients with g3 lesions are poorly defined. Materials and methods We evaluated outcomes in 37 consecutive kidney transplant biopsies diagnosed with g3 glomerulitis based on Banff 2013 criteria in a single-center observational study. Results The diagnosis of g3 glomerulonephritis was made 6.1 ± 6.6 years after transplant. The majority of patients were Caucasian (86%), male (65%), and received basiliximab induction (54%). At the time of biopsy, all were on triple therapy with tacrolimus, mycophenolate, and prednisone. Mean serum creatinine (Scr) was 2.85 ± 2.1 mg/dL. Notably, 20 (54%) were positive for donor-specific antibodies (DSA+) and 8 (22%) were C4d+, while 24 (65%) had transplant glomerulopathy (TG). Treatment included pulse steroids/intravenous immunoglobulin (IVIG) (73%) and rituximab (51%). Patients were followed for up to 4 years after the biopsy. Eleven grafts (30%) were lost during the follow-up. Cox regression analyses determined Scr (HR = 1.63, 95% CI 1.19 - 2.24, p = 0.002), live donor status (HR = 0.18, 95% CI 0.04 - 0.90, p = 0.03), t-score (HR = 2.75, 95% CI 1.30 - 5.81, p = 0.008), and ct-score (HR = 2.19, 95% CI 1 - 4.75, p = 0.04) as significant predictors of graft loss. Conclusion Severe glomerulitis was associated with a high prevalence of TG and graft loss at 4 years. Live donor status, kidney function (Scr), and tubular injury (t- and ct-scores) were independently associated with graft loss. Interventional mechanistic clinical trials are needed to better understand the pathogenesis and outcomes of g3 glomerulitis. . |
| Databáze: | OpenAIRE |
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