Elevated frequency of CD1c+ myeloid dendritic cells in the peripheral blood mononuclear cells of simian/human immunodeficiency virus (SHIV) and simian immunodeficiency virus (SIV) repeatedly infected Chinese rhesus macaques
| Autor: | Jia-zhong Duan, Chun-Miao Zong, Gui-bo Yang, Na Lei, Yiming Shao, Hui Xing |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
China
Myeloid Immunology Simian Acquired Immunodeficiency Syndrome C-C chemokine receptor type 7 HIV Infections Biology medicine.disease_cause Peripheral blood mononuclear cell Flow cytometry Antigens CD1 medicine Animals Humans Myeloid Cells CD86 CD11b Antigen medicine.diagnostic_test Dendritic Cells HLA-DR Antigens Simian immunodeficiency virus Antigens CD20 Flow Cytometry Virology Macaca mulatta Endocytosis medicine.anatomical_structure Integrin alpha M biology.protein Leukocytes Mononuclear Interleukin-3 receptor B7-2 Antigen |
| Zdroj: | Cellular immunology. 271(1) |
| ISSN: | 1090-2163 |
| Popis: | CD1c+ myeloid dendritic cells (mDCs) in the peripheral blood of 30 SHIV-SF162p4 and SIVmac251 sequentially infected Chinese rhesus macaques were examined by flow cytometry to obtain further insight into mDC alterations in HIV/AIDS. The CD1c+ cells were found to be mononuclear leukocytes rather than granulocytes, and most of them expressed CD20. CD1c+mDCs (CD1c+CD20−) consisted of two morphological subsets: the granular and the large CD1c+mDCs. The expression of HLA-DR, CD86, and CD11b, but no CCR7, CD83 and CD123, together with their endocytotic capacity indicated that they were immature mDCs. Their frequency at weeks 10 and 12 post-infection was significantly higher than that of un-infected ones; the large CD1c+mDC level was significantly different between time points and almost absent from un-infected rhesus monkeys; significant correlations between CD1c+mDCs and plasma viral load levels were also observed. These data indicated a possible role for CD1c+mDCs in the pathophysiological process of SIV/HIV infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect