A Phase II Study of Tumor-infiltrating Lymphocyte Therapy for Human Papillomavirus-associated Epithelial Cancers
Autor: | John R. Wunderlich, Robert Somerville, Udai S. Kammula, James Chih-Hsin Yang, Richard M. Sherry, Steven A. Rosenberg, Sarah R. Helman, Mei Li M. Kwong, Michelle M. Langhan, Christopher A. Klebanoff, Stacey L. Doran, Christian S. Hinrichs, Sanja Stevanović |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Oncology Adult Male Cancer Research medicine.medical_specialty medicine.medical_treatment Immunotherapy Adoptive Article Cell therapy 03 medical and health sciences 0302 clinical medicine Lymphocytes Tumor-Infiltrating Aldesleukin Internal medicine medicine Anal cancer Humans Papillomaviridae Cervical cancer biology business.industry Carcinoma Papillomavirus Infections Cancer Immunotherapy Middle Aged medicine.disease biology.organism_classification Clinical trial 030104 developmental biology Treatment Outcome 030220 oncology & carcinogenesis Female business Tomography X-Ray Computed |
Zdroj: | Clinical cancer research : an official journal of the American Association for Cancer Research. 25(5) |
ISSN: | 1557-3265 |
Popis: | Purpose: Cellular therapy is an emerging cancer treatment modality, but its application to epithelial cancers has been limited. This clinical trial evaluated tumor-infiltrating lymphocyte (TIL) therapy for the treatment of patients with metastatic human papillomavirus (HPV)-associated carcinomas. Patients and Methods: The trial was a phase II design with two cohorts, cervical cancers and noncervical cancers. Cell infusion was preceded by a lymphocyte-depleting conditioning regimen and followed by systemic high-dose aldesleukin. Results: Objective tumor responses occurred in 5 of 18 (28%) patients in the cervical cancer cohort and 2 of 11 (18%) patients in the noncervical cancer cohort. Two of the responses in cervical cancer were complete and are ongoing 67 and 53 months after treatment. Responses in the noncervical cancer cohort were in anal cancer and oropharyngeal cancer. The HPV reactivity of the infused T cells correlated with clinical response. Peripheral blood repopulation with HPV-reactive T cells also correlated with clinical response. Conclusions: These findings support the concept that cellular therapy can mediate the regression of epithelial cancers, and they suggest the importance of predictive biomarkers and novel treatment platforms for more effective therapies. |
Databáze: | OpenAIRE |
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