Radionuclide therapy: current status and prospects for internal dosimetry in individualized therapeutic planning
| Autor: | José Willegaignon, Marcelo Tatit Sapienza |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Time Factors MEDLINE Review Article 030204 cardiovascular system & hematology Neuroendocrine tumors law.invention 03 medical and health sciences Prostate cancer 0302 clinical medicine Randomized controlled trial law medicine Dosimetry Image acquisition Humans Internal dosimetry Medical physics 030212 general & internal medicine Radionuclide Imaging Radiometry Radioisotopes Tomography Emission-Computed Single-Photon lcsh:R5-920 Radiotherapy business.industry In vivo Dosimetry General Medicine medicine.disease Positron-Emission Tomography Radionuclide therapy Nuclear Medicine business lcsh:Medicine (General) |
| Zdroj: | Clinics Clinics; v. 74 (2019); e835 Clinics; Vol. 74 (2019); e835 Universidade de São Paulo (USP) instacron:USP Clinics, Volume: 74, Article number: e835, Published: 29 JUL 2019 Clinics, Vol 74 |
| ISSN: | 1980-5322 1807-5932 |
| Popis: | The efficacy and toxicity of radionuclide therapy are believed to be directly related to the radiation doses received by target tissues; however, nuclear medicine therapy continues to be based primarily on the administration of empirical activities to patients and less frequently on the use of internal dosimetry for individual therapeutic planning. This review aimed to critically describe the techniques and clinical evidence of dosimetry as a tool for therapeutic planning and the main limitations to its implementation in clinical practice. The present article is a nonsystematic review of voxel-based dosimetry. Clinical evidence pointing to a correlation between the radiation dose and therapeutic response in various diseases, such as thyroid carcinoma, neuroendocrine tumors and prostate cancer, is reviewed. Its limitations include technical aspects related to image acquisition and processing and the lack of randomized clinical trials demonstrating the impact of dosimetry on patient therapy. A more widespread use of dosimetry in therapeutic planning involves the development of user-friendly dosimetric protocols and confirmation that dose estimation implies good efficacy and low treatment-related toxicity. |
| Databáze: | OpenAIRE |
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