Concentrations of amyloid-beta protein in cerebrospinal fluid increase with age in patients free from neurodegenerative disease
| Autor: | W.A. van Gool, D.B. Schenk, Pieter A. Bolhuis |
|---|---|
| Přispěvatelé: | Other departments |
| Rok vydání: | 1994 |
| Předmět: |
Senescence
Adult medicine.medical_specialty Pathology Aging Central nervous system Enzyme-Linked Immunosorbent Assay Disease Pathogenesis Cerebrospinal fluid Internal medicine medicine Amyloid precursor protein Humans Risk factor Aged Aged 80 and over Amyloid beta-Peptides biology business.industry General Neuroscience Middle Aged medicine.disease medicine.anatomical_structure Endocrinology biology.protein Alzheimer's disease Nervous System Diseases business |
| Zdroj: | Neuroscience letters, 172(1-2), 122-124. Elsevier Ireland Ltd |
| ISSN: | 0304-3940 |
| Popis: | Cerebral deposition of amyloid-beta protein (A beta) is central to the pathogenesis of Alzheimer's disease (AD). Increasing age is one of the few definitively established risk factors for this disease. The concentration of A beta was measured in cerebrospinal fluid (CSF) with a sensitive enzyme-linked immunosorbent assay in 18 adult neurological patients free from neurodegenerative disease. CSF A beta increased with age, yielding a significant correlation of 0.84. This observation suggests that increased levels of A beta in CSF may be an index of age-related changes in the processing of the amyloid-beta precursor protein resulting in an increased risk for AD. |
| Databáze: | OpenAIRE |
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