Transgenic mice that express different forms of the influenza virus hemagglutinin as a neo-self-antigen
| Autor: | D. M. Cerasoli, Andrew J. Caton, Fei F. Shih, S. E. Stark |
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| Rok vydání: | 1995 |
| Předmět: |
chemistry.chemical_classification
Base Sequence Transgene Molecular Sequence Data Immunology Orthomyxoviridae Hemagglutinins Viral Mice Transgenic Biology Hemagglutinin biology.organism_classification Autoantigens Virology Virus Epitope Immune tolerance Mice chemistry Antigen Influenza A virus Immune Tolerance Animals Immunology and Allergy Glycoprotein Antigens Viral |
| Zdroj: | Journal of Clinical Immunology. 15:S106-S112 |
| ISSN: | 1573-2592 0271-9142 |
| DOI: | 10.1007/bf01540900 |
| Popis: | We have generated transgenic mouse lineages that express the influenza virus hemagglutinin in different physical forms. One kind expresses the full-length hemagglutinin molecule as a cell surface glycoprotein and can be recognized by hemagglutinin-specific B and T cells. The other expresses a truncated polypeptide corresponding to the N-terminal third of the hemagglutinin molecule. This polypeptide encodes known hemagglutinin-specific T-cell determinants; however, it contains no native B-cell epitopes, since these depend on the conformation of the fully folded protein. In each case, the hemagglutinin transgenic mice display ubiquitous expression of transgenic messenger RNA and induce T-cell tolerance to the transgene-encoded T-cell determinant site 1. Thus, the hemagglutinin is a neo-self-antigen in both kinds of hemagglutinin transgenic mice and should provide a useful system for understanding the factors and mechanisms that govern tolerance and autoimmunity to self-antigens. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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