Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão
| Autor: | Vanda Maria Ferreira Simões, Marcos Adriano Garcia Campos, Léa Márcia Melo da Costa, Maylla Luanna Barbosa Martins Bragança, Conceição de Maria Pedrozo e Silva de Azevedo, Maria Teresa Seabra Soares de Brito e Alves, Bruno Feres de Souza, Eudes Alves Simões-Neto, Vitória Abreu de Carvalho, Carolina Abreu de Carvalho, Lécia Maria Sousa Santos Cosme, Lídio Gonçalves Lima-Neto, Antônio Augusto Moura da Silva, Rejane Christine de Sousa Queiroz, Erika Bárbara Abreu Fonseca Thomaz, Alcione Miranda dos Santos, Allan Kardec Duailibe Barros Filho, Jamesson Ferreira Leite Júnior, Bruno Luciano Carneiro Alves de Oliveira, Bernardo Bastos Wittlin, Sérgio Costa |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Immunity Herd Male Adolescent Population Antibodies Viral Asymptomatic Herd immunity 03 medical and health sciences Young Adult Seroepidemiologic Studies Case fatality rate Pandemic Medicine Seroprevalence Humans Young adult Mortality education Child Pandemics Aged education.field_of_study 030505 public health business.industry SARS-CoV-2 Public Health Environmental and Occupational Health Infant Newborn COVID-19 Infant Middle Aged Child Preschool Original Article Female medicine.symptom Public aspects of medicine RA1-1270 0305 other medical science business Coronavirus Infections Brazil Demography |
| Zdroj: | Revista de Saúde Pública, Volume: 54, Article number: 131, Published: 14 DEC 2020 Revista de Saúde Pública, Vol 54 (2020) Revista de Saúde Pública Revista de Saúde Pública v.54 2020 Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1518-8787 |
| Popis: | OBJECTIVE: To estimate the seroprevalence of SARS-CoV-2 in the state of Maranhão, Brazil. METHODS: A population-based household survey was performed, from July 27, 2020 to August 8, 2020. The estimates considered clustering, stratification and non-response. Qualitative detection of IgM and IgG antibodies was performed in a fully-automated Elecsys® Anti-SARS-CoV-2 electrochemiluminescence immunoassay on the Cobas® e601 analyzer (Roche Diagnostics). RESULTS: In total, 3,156 individuals were interviewed. Seroprevalence of total antibodies against SARS-CoV-2 was 40.4% (95%CI 35.6-45.3). Population adherence to non-pharmaceutical interventions was higher at the beginning of the pandemic than in the last month. SARS-CoV-2 infection rates were significantly lower among mask wearers and among those who maintained social and physical distancing in the last month compared to their counterparts. Among the infected, 26.0% were asymptomatic. The infection fatality rate (IFR) was 0.14%, higher for men and older adults. The IFR based on excess deaths was 0.28%. The ratio of estimated infections to reported cases was 22.2. CONCLUSIONS: To the best of our knowledge, the seroprevalence of SARS-CoV-2 estimated in this population-based survey is one of the highest reported. The local herd immunity threshold may have been reached or might be reached soon. |
| Databáze: | OpenAIRE |
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