Chlamydia trachomatis antibody detection and diagnosis of reactive arthritis
| Autor: | S Bas, T L Vischer |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Immunoglobulin A Sexually transmitted disease Adolescent Porins Arthritis Chlamydia trachomatis Enzyme-Linked Immunosorbent Assay medicine.disease_cause Arthritis Reactive Immunoglobulin G Rheumatology Antigen Predictive Value of Tests Synovial Fluid Humans Medicine Pharmacology (medical) Reactive arthritis Aged Antigens Bacterial biology business.industry Chlamydia Infections Middle Aged medicine.disease Antibodies Bacterial Recombinant Proteins Evaluation Studies as Topic Immunology biology.protein Female Antibody business Bacterial Outer Membrane Proteins |
| Zdroj: | Rheumatology. 37:1054-1059 |
| ISSN: | 1460-2172 |
| Popis: | SUMMARY Objective. To investigate whether determining the presence of serum or synovial fluid (SF ) IgG and IgA of anti-Chlamydia antibodies with two recent commercially available enzyme-linked immunosorbent assays (ELISA) using synthetic peptides or recombinant antigen could be helpful to detect possible Chlamydia trachomatis (CT )-involved disease in rheumatological patients without evidence of urogenital CT infection. Methods. The prevalence of such antibodies was determined in samples from patients with well-defined disease, i.e. CT sexually acquired arthritis and from patients with other inflammatory arthropathies unrelated to CT. Results. When considering IgG and/or IgA anti-MOMP or anti-LPS antibodies, a sensitivity of 100% was obtained for serum and SF samples, but with a low specificity. A sensitivity and a specificity equal or close to 80% were observed for the SF IgG anti-MOMP antibodies. Conclusion. Clinically, the most appropriate determination was the SF IgG anti-MOMP antibodies. This commercially available ELISA test could be useful for the diagnosis of probable CT reactive arthritis. |
| Databáze: | OpenAIRE |
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