Effects of dietary iron restriction on kidney mitochondria function and oxidative stress in streptozotocin-diabetic rats
| Autor: | Donovan J. Peña-Montes, Xóchitl Trujillo, Miguel Huerta, Maribel Huerta-Cervantes, Mónica Ríos-Silva, Alfredo Saavedra-Molina, Christian Cortés-Rojo |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Iron Cell Respiration Mitochondrion medicine.disease_cause Streptozocin Diabetes Mellitus Experimental 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Diabetes mellitus parasitic diseases medicine Animals Rats Wistar Respiratory system Molecular Biology Kidney business.industry Iron Deficiencies Cell Biology Glutathione Streptozotocin medicine.disease Mitochondria Rats Oxidative Stress Treatment Outcome 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry Molecular Medicine business Iron Dietary 030217 neurology & neurosurgery Function (biology) Oxidative stress medicine.drug |
| Zdroj: | Mitochondrion. 54:41-48 |
| ISSN: | 1567-7249 |
| Popis: | Diabetes mellitus is characterized by chronic hyperglycemia causing mitochondrial dysfunction and kidney iron overload has been observed during diabetes. We evaluated the effects of an iron-restricted diet (IRD) on mitochondrial function, oxidative stress, and mitochondrial iron levels in the kidneys of Wistar rats with streptozotocin-induced diabetes. IRD ameliorated mitochondrial dysfunction in diabetic rats by restoring mitochondrial respiration and respiratory complex activity, improving oxidative stress and glutathione status in kidney mitochondria. We also observed mitochondrial iron overload. Our data suggest that elevated iron levels were attenuated by IRD, resulting in modulation of oxidative stress and mitochondrial function in the kidney. |
| Databáze: | OpenAIRE |
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