Regional Adipose Tissue Metabolism in Postmenopausal Women After Treatment with Exogenous Sex Steroids
| Autor: | Ulla-Beth Lindberg, G. Silfverstolpe, N. Crona, M. Rebuffé-Scrive, Per Björntorp |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Blood Glucose
medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism Clinical Biochemistry Administration Oral Adipose tissue Blood Pressure Administration Cutaneous Ethinyl Estradiol Biochemistry Norepinephrine (medication) Endocrinology Sex Hormone-Binding Globulin Internal medicine medicine Humans Insulin Lipolysis Progesterone Triglycerides Lipoprotein lipase Estradiol business.industry Body Weight Biochemistry (medical) Estrogens General Medicine Metabolism Middle Aged Norethisterone acetate Adipose Tissue Estrogen Drug Therapy Combination Female Follicle Stimulating Hormone Menopause Norethindrone business medicine.drug Hormone |
| Zdroj: | Hormone and Metabolic Research. 22:345-351 |
| ISSN: | 1439-4286 0018-5043 |
| Popis: | In order to evaluate the effect of exogenous sex steroids on adipose tissue metabolism, two groups of postmenopausal women were studied. In one of the groups, the effect of 50 micrograms ethinyl estradiol (EE) was investigated given orally alone and in combination with 10 mg norethisterone acetate (NET). This combination is reminiscent of an old high dose oral contraceptive. In the other group, the effect of 3 mg 17 beta-estradiol was evaluated when administered percutaneously alone and in combination with 300 mg micronized progesterone given orally. These substances and doses were chosen to provide a "physiological" hormonal influence. In the femoral region 50 micrograms EE induced an increase in LPL activity. This elevated LPL value was reversed with the addition of 10 mg NET. Moreover, during treatment with 50 micrograms EE, a decrease in norepinephrine stimulated lipolysis was seen in the abdominal region. The percutaneous administration of 17 beta-estradiol with or without micronized progesterone, however, was inert as regards subcutaneous adipose tissue metabolism. Our findings indicate, therefore, that EE in doses used in oral contraception might promote lipid accumulation in the femoral adipose tissue depot. |
| Databáze: | OpenAIRE |
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