Relation of Tricuspid Regurgitation to Liver Stiffness Measured by Transient Elastography in Patients With Left-Sided Cardiac Valve Disease
| Autor: | James Fung, Yan Chen, Chu-Pak Lau, Lai-Ming Ho, Man-Hong Jim, Ju-Hua Liu, Hung-Fat Tse, Gabriel W.K. Yip, Katherine Fan, Kai-Hang Yiu, Man-Fung Yuen, Wai-Kay Seto, Zhe Zhen |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Echocardiography Three-Dimensional 030204 cardiovascular system & hematology Severity of Illness Index Ventricular Dysfunction Left 03 medical and health sciences 0302 clinical medicine Tricuspid Valve Insufficiency Liver stiffness Internal medicine Severity of illness medicine Humans In patient Heart valve Aged Retrospective Studies Tricuspid valve business.industry Central venous pressure Reproducibility of Results Middle Aged Elasticity Echocardiography Doppler Color medicine.anatomical_structure Liver Cardiology Elasticity Imaging Techniques Female 030211 gastroenterology & hepatology Tricuspid Valve Cardiology and Cardiovascular Medicine Transient elastography business Follow-Up Studies |
| Zdroj: | The American Journal of Cardiology. 117:640-646 |
| ISSN: | 0002-9149 |
| Popis: | The aim of the study was to evaluate the relation between tricuspid regurgitation (TR) severity and liver stiffness (LS) in patients with TR. A total of 131 patients with various degrees of TR secondary to left-sided heart valve disease were enrolled. Severity of TR was quantitatively assessed by proximal isovelocity surface area-derived effective regurgitant orifice (ERO). Patients were divided into 2 groups: 48 with mild-moderate TR (ERO0.4 cm(2)) and 83 with severe TR (ERO ≥0.4 cm(2)). Transient elastography was used to measure the level of LS, an established marker of liver fibrosis, with the threshold of significant LS set at ≥12.5 kPa. Patients with severe TR had a higher LS and prevalence of significant LS than those with mild-moderate TR. Furthermore, LS and significant LS independently correlated with TR-ERO, right atrial pressure and inferior vena cava (IVC) diameter. The presence of a large TR-ERO (≥0.4 cm(2)) and IVC diameter (2.15 cm(2)) provided a high specificity of 78% for significant LS. In conclusion, the present study demonstrates that TR-ERO, right atrial pressure, and IVC diameter are important parameters associated with LS in patients with TR. |
| Databáze: | OpenAIRE |
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