Pharmacokinetics of metoclopramide in calves with renal dysfunction
| Autor: | Toshihiro Ichijo, Kazuhisa Furuhama, Mariko Takayasu, Hiroshi Satoh, Toru Takahashi, Kouko Hamamoto |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Metoclopramide medicine.medical_treatment Cattle Diseases Renal function Nephrectomy Pharmacokinetics renal dysfunction Internal medicine Animals Medicine Renal Insufficiency Ligation Pharmacology calf glomerular filtration rate Kidney General Veterinary business.industry Half-life Note Iodixanol medicine.anatomical_structure Endocrinology Area Under Curve Antiemetics Cattle business Half-Life medicine.drug |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 1347-7439 0916-7250 |
| DOI: | 10.1292/jvms.14-0301 |
| Popis: | To clarify the effect of renal dysfunction on pharmacokinetics of the prokinetic agent metoclopramide (MCP), we administered intravenously 0.4 mg/kg MCP to healthy calves and calves subjected to right kidney vessel ligation (ligation) without or with a subsequent left nephrectomy (ligation plus removal). Plasma MCP concentration, glomerular filtration rate (GFR) and plasma prolactin level were measured by liquid chromatography-tandem mass spectrometry, simplified equation using iodixanol and enzyme-linked immunosorbent assay, respectively. Only in calves with ligation plus removal, plasma MCP concentrations were increased significantly 6, 8 and 12 hr after injection, showing that a negative correlation was observed between the plasma MCP concentrations and GFR value. A tendency to increase in plasma PRL concentration was noted also in these calves. In conclusions, plasma MCP concentrations depend on the GFR mode in calves, and its critical GFR value was estimated. |
| Databáze: | OpenAIRE |
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