Concurrent stem- and lineage-affiliated chromatin programs precede hematopoietic lineage restriction

Autor: Fatemeh, Safi, Parashar, Dhapola, Sarah, Warsi, Mikael, Sommarin, Eva, Erlandsson, Jonas, Ungerbäck, Rebecca, Warfvinge, Ewa, Sitnicka, David, Bryder, Charlotta, Böiers, Ram Krishna, Thakur, Göran, Karlsson
Rok vydání: 2022
Předmět:
Zdroj: Cell Reports. 39:110798
ISSN: 2211-1247
Popis: The emerging notion of hematopoietic stem and progenitor cells (HSPCs) as a low-primed cloud without sharply demarcated gene expression programs raises the question on how cellular-fate options emerge and at which stem-like stage lineage priming is initiated. Here, we investigate single-cell chromatin accessibility of Lineage
Databáze: OpenAIRE