GRGDS-Functionalized Poly(lactide)-graft-poly(ethylene glycol) Copolymers: Combining Thiol–Ene Chemistry with Staudinger Ligation
Autor: | Dorothee E. Borchmann, Niels ten Brummelhuis, Marcus Weck |
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Rok vydání: | 2013 |
Předmět: | |
Zdroj: | Macromolecules. 46:4426-4431 |
ISSN: | 1520-5835 0024-9297 |
Popis: | A tri(ethylene glycol)-containing lactide analogue was synthesized via thiol-ene chemistry between a bi-functional triethylene glycol and allyl lactide. Subsequent tin-octoate-catalyzed ring-opening polymerization yielded well-defined poly(lactide)-graft-poly(ethylene glycol) copolymers with molecular weights of 6000 g/mol and polydispersity indices of 1.6. The tri(ethylene glycol) chains along the copolymers contain azide termini that are capable of ‘click’-type postpolymerization functionalization. The utility of this strategy was demonstrated via successful Staudinger ligation to install the Gly-Arg-Gly-Asp-Ser (GRGDS) peptide. |
Databáze: | OpenAIRE |
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