GRGDS-Functionalized Poly(lactide)-graft-poly(ethylene glycol) Copolymers: Combining Thiol–Ene Chemistry with Staudinger Ligation

Autor: Dorothee E. Borchmann, Niels ten Brummelhuis, Marcus Weck
Rok vydání: 2013
Předmět:
Zdroj: Macromolecules. 46:4426-4431
ISSN: 1520-5835
0024-9297
Popis: A tri(ethylene glycol)-containing lactide analogue was synthesized via thiol-ene chemistry between a bi-functional triethylene glycol and allyl lactide. Subsequent tin-octoate-catalyzed ring-opening polymerization yielded well-defined poly(lactide)-graft-poly(ethylene glycol) copolymers with molecular weights of 6000 g/mol and polydispersity indices of 1.6. The tri(ethylene glycol) chains along the copolymers contain azide termini that are capable of ‘click’-type postpolymerization functionalization. The utility of this strategy was demonstrated via successful Staudinger ligation to install the Gly-Arg-Gly-Asp-Ser (GRGDS) peptide.
Databáze: OpenAIRE