Genome-Wide Association Study of Body Mass Index and Body Fat in Mexican-Mestizo Children
| Autor: | Jacqueline Solares-Tlapechco, Iván de Jesús Ascencio-Montiel, Martha Eunice Rodríguez-Arellano, Miryam Ramirez-Alcántara, Angélica Saraí Jiménez-Osorio, Paula Costa-Urrutia, Julio Granados, Helios Cárdenas-Hernández, Valentina Colistro |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Genetic Markers
Male 0301 basic medicine Pediatric Obesity lcsh:QH426-470 Adolescent Genotype 030209 endocrinology & metabolism Genome-wide association study Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Article Childhood obesity Body Mass Index BMI 03 medical and health sciences 0302 clinical medicine Classification of obesity percent of body fat Prevalence Genetics medicine Humans GWAS 1000 Genomes Project Child Mexico Genetics (clinical) Adiposity childhood medicine.disease Obesity lcsh:Genetics 030104 developmental biology Genetic Loci Child Preschool Female Body mass index Imputation (genetics) Genome-Wide Association Study Demography |
| Zdroj: | Genes Volume 10 Issue 11 Genes, Vol 10, Iss 11, p 945 (2019) |
| ISSN: | 2073-4425 |
| DOI: | 10.3390/genes10110945 |
| Popis: | Background: Childhood obesity is a major health problem in Mexico. Obesity prevalence estimated by body mass index (BMI) is almost half than that estimated by percent body fat (%BF) in the Childhood Obesity pediatric cohort (COIPIS). Objective. We performed a genome-wide association study (GWAS) of BMI and %BF in 828 children from the COIPIS to identify markers of predisposition to high values for both phenotypes used for obesity classification. Methods: For the GWAS we used the LAT Axiom 1, Affymetrix and 2.5 million single loci from the 1000 Genomes Phase 3 imputation panel. We used a linear model, adjusted by age, sex, and Amerindian ancestry assuming an additive inheritance model. Results. Genome-wide significance (p &le 5.0 × 10&minus 8) and 80% of statistical power was reached for associations of two loci in two genes (CERS3 and CYP2E1) to BMI. Also, 11 loci in six genes (ANKS1B, ARNTL2, KCNS3, LMNB1, SRGAP3, TRPC7) reached genome-wide significance for associations to %BF, though not 80% of statistical power. Discussion: None of the SNPs were previously reported as being associated to BMI or %BF. In addition, different loci were found for BMI and %BF. These results highlight the importance of gaining deeper understanding of genetic markers of predisposition to high values for the phenotypes used for obesity diagnosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|