Epinephrine exerts anticoagulant effects during human endotoxemia
| Autor: | S. F. Lowry, S. M. Coyle, W. A. Buurman, Marcel Levi, J W ten Cate, T van der Poll, M. Dentener, C. E. Hack, P. M. Jansen, C.C. Braxton |
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| Přispěvatelé: | Faculteit der Geneeskunde, Other departments |
| Rok vydání: | 1997 |
| Předmět: |
Adult
Lipopolysaccharides Male medicine.medical_specialty Epinephrine Plasmin medicine.medical_treatment Immunology Tissue plasminogen activator chemistry.chemical_compound Alpha 2-antiplasmin Internal medicine Plasminogen Activator Inhibitor 1 Fibrinolysis Escherichia coli medicine Humans Immunology and Allergy Fibrinolysin Infusions Intravenous Blood Coagulation Disseminated intravascular coagulation Hemostasis alpha-2-Antiplasmin Brief Definitive Report Anticoagulants medicine.disease Endotoxemia Endocrinology chemistry Tissue Plasminogen Activator Plasminogen activator inhibitor-1 Anesthesia Brief Definitive Reports Plasminogen activator medicine.drug |
| Zdroj: | Journal of Experimental Medicine, 185, 1143-1148. Rockefeller University Press The Journal of Experimental Medicine Journal of experimental medicine, 185(6), 1143-1148. Rockefeller University Press |
| ISSN: | 0022-1007 |
| Popis: | To determine the effect of a physiologically relevant elevation in the plasma concentrations of epinephrine on the activation of the hemostatic mechanism during endotoxemia, 17 healthy men were studied after intravenous injection of lipopolysaccharide (LPS, 2 ng/kg), while receiving a continuous infusion of epinephrine (30 ng/kg/min) started either 3 h (n = 5) or 24 h (n = 6) before LPS injection, or an infusion of normal saline (n = 6). Activation of the coagulation system (plasma concentrations of thrombin–antithrombin III complexes and prothrombin fragment F1+2) was significantly attenuated in the groups treated with epinephrine when compared with subjects injected with LPS only (P 50%. Hence, epinephrine exerts antithrombotic effects during endotoxemia by concurrent inhibition of coagulation, and stimulation of fibrinolysis. Epinephrine, whether endogenously produced or administered as a component of treatment, may limit the development of disseminated intravascular coagulation during systemic infection. |
| Databáze: | OpenAIRE |
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