Mixed ligand complex via zinc(II)-mediated in situ oxidative heterocyclization of hydrochloride salt of 2-chlorobenzaldehyde hydralazine hydrazone as potential of antihypertensive agent
| Autor: | Chandrashekhar V. Mangannavar, Iranna S. Muchchandi, Raghavendra P. Bakale, Christopher S. Frampton, Igor N. Shcherbakov, Ganesh N. Naik, Kalagouda B. Gudasi |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Stereochemistry Hydrochloride Triazole chemistry.chemical_element Hydrazone Fructose Zinc Crystallography X-Ray Ligands Medicinal chemistry Rats Sprague-Dawley Metal chemistry.chemical_compound Coordination Complexes Nickel Drug Discovery Animals Antihypertensive Agents Pharmacology chemistry.chemical_classification Molecular Structure Organic Chemistry Hydrazones 1 2 4-Triazole Cobalt General Medicine Hydralazine Rats chemistry Cyclization Benzaldehydes visual_art Hypertension Thermogravimetry visual_art.visual_art_medium Phthalazine Oxidation-Reduction Copper |
| Zdroj: | European Journal of Medicinal Chemistry. 73:38-45 |
| ISSN: | 0223-5234 |
| DOI: | 10.1016/j.ejmech.2013.11.037 |
| Popis: | An unusual tetrahedral mixed ligand Zn(II) complex ZnT(L)Cl, where L = 2-chlorobenzaldehyde hydralazine hydrazone and T = in situ generated 3-(2-chlorophenyl)-1,2,4-triazolo[3,4-a]phthalazine is reported. Structure of the fused triazole has been confirmed by single crystal X-ray diffraction studies. Structure of Co(II), Ni(II), Cu(II) and Zn(II) complexes has been confirmed by spectral and analytical methods. Metal complexes have exhibited better activity in the fructose induced hypertension studies in animal model and are comparable with the standard. |
| Databáze: | OpenAIRE |
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