Traffic to the inner membrane of the nuclear envelope
| Autor: | Liesbeth M. Veenhoff, Anton Steen, Justyna K Laba |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
CHROMATIN
Cytoplasm Nuclear Envelope PROTEIN DISTINCT MECHANISMS PORE COMPLEX Mitochondrial membrane transport protein DOMAIN Membrane Protein Traffic Animals Humans Inner membrane POM121 LAMIN-B RECEPTOR ARCHITECTURE biology Membrane transport protein Biological Transport Cell Biology Membrane transport TRANSPORT Cell biology Transport protein Kinetics Membrane protein Translocase of the inner membrane biology.protein |
| Zdroj: | Current Opinion in Cell Biology. 28:36-45 |
| ISSN: | 0955-0674 |
| DOI: | 10.1016/j.ceb.2014.01.006 |
| Popis: | Past research has yielded valuable insight into the mechanisms that regulate the nuclear transport of soluble molecules like transcription factors and mRNA. Much less is known about the mechanisms responsible for the transportation of membrane proteins to the inner membrane of the nuclear envelope. The key question is: does the facilitated transport of integral inner membrane proteins exist in the same way as it does for soluble proteins and, if so, what is it used for? Herein, we provide an overview of the current knowledge on traffic to the inner nuclear membrane, and make a case that: (a) known sorting signals and molecular mechanisms in membrane protein biogenesis, membrane protein traffic and nuclear transport are also relevant with respect to INM traffic; and (b) the interplay of the effects of these signals and molecular mechanisms is what determines the rates of traffic to the INM. |
| Databáze: | OpenAIRE |
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